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败血症患者的HALP得分和住院死亡率之间的关联:一个多中心的回顾性队列研究与外部验证

Xingping Lv¹, Xiaobin Liu¹, Yezhou Shen¹

¹Department of Critical Care Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.

Frontiers in public health

|January 28, 2026

概括

血红蛋白,白蛋白,淋巴细胞和血小板 (HALP) 评分有效预测败血症死亡率. 较高的HALP得分与败血症患者的住院死亡风险降低有关.

科学领域:

关键护理医学关键护理医学
生物统计学生物统计学
临床病理学临床病理学

背景情况:

血红蛋白,白蛋白,淋巴细胞和血小板 (HALP) 评分结合了营养和免疫标记.
它对败血症患者住院死亡率的预后效用需要进一步调查.

研究的目的:

评估HALP得分与败血症患者住院死亡率之间的关联.
在两个大型重症监护数据库中验证发现.

主要方法:

使用eICU和MIMIC-IV数据库 (共16625名成人败血症患者) 的回顾性队列研究.
使用初始ICU入院值计算的HALP得分: (血红蛋白 × 白蛋白 × 淋巴细胞计数) /血小板计数.
限制立方线,卡普兰-梅尔曲线和多变量考克斯回归分析了HALP死亡率关系.

主要成果:

在两个队列中观察到HALP得分和住院死亡率之间的显著非线性关联 (P < 0.001).
较低的HALP得分与死亡风险的增加相关;每个单位的增加低于一个拐点,风险降低3%.
在完全调整后,高HALP得分显示出对住院死亡率的独立保护作用 (例如,MIMIC-IV:HR 0.85,P = 0.028).

结论:

哈尔普得分具有重要的预后价值,用于预测败血症的住院死亡率.
在大型数据库中,在不同患者群体中,得分的预测性能得到了一致的证明.
它从常规实验室计算的方便性表明了在败血症管理中临床风险分层的潜力.

关键词:

半个分数的得分是半个分数.在医院的死亡率.预后预后预后风险分层的分层化这是一种血症.

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