参与药理动力学的肝酶和输送体的性别差异
Mehak Behal1, Zachary McCalla1, Xinwen Wang1
1Department of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH, USA.
Liver research (Beijing, China)
|January 28, 2026
概括
由于基于性别的药理动力学差异,女性的药物不良反应发生率是女性的两倍. 了解这些特定于性别的药物代谢和运输变异对于更安全的药物使用至关重要.
科学领域:
- 药理学 药理学是指药理学的学科.
- 生物化学 生物化学
- 临床药房 临床药房
背景情况:
- 与男性相比,女性的药物不良反应 (ADR) 发生率大约是男性的两倍.
- 基于性别的药理动力学差异,特别是肝脏药物代谢和运输的差异,与这种ADR差异密切相关.
- 关于药物代谢酶和转运体对性别特异性影响的现有研究是分散的,需要一个整合的概述.
研究的目的:
- 综合审查和分析有关肝脏关键药物代谢酶和载体的表达和活性性别差异的现有数据.
- 总结这些基于性别的差异对临床药理动力学,副作用和药物剂量的影响.
- 探索潜在的潜在机制,并讨论性信息化药物治疗的临床影响.
主要方法:
- 对肝脏药物代谢酶 (例如CYP,UGT,CES) 和输送体 (例如P-gp,BCRP,MRP,OATP,OCT) 的性别差异现有文献的系统编译和分析.
- 酶/载体表达和活性数据的跨物种比较.
- 对调查性别差异对药物药理动力学和临床结果的影响的研究的综述.
- 探索包括性激素,染色体和生活方式在内的机械因素.
主要成果:
- 在各种物种中,肝脏主要药物代谢酶和转运体的表达和/或活性存在显著的基于性别的变异.
- 这些药物动力学差异可以显著改变药物暴露,疗效和毒性,导致性别之间的ADR率差异.
- 性激素,性染色体和生活方式因素被确定为这些观察到的性别特异性影响的潜在贡献者.
结论:
- 肝脏药物代谢和运输中的性别差异显著影响药物反应,并导致女性的ADR率更高.
- 迫切需要更多以人为中心的研究来阐明这些性别特异性影响,并为个性化药物治疗提供信息.
- 制定基于性别的药物剂量策略对于改善治疗结果和减少与药物相关的发病率和死亡率至关重要.
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