现型衰老对美国成年人癌症史和死亡率之间的关系的影响
Meng-Hua Tao1,2, Chun-Hui Lin1, Shu-Chun Chuang3
1Department of Public Health Sciences, Henry Ford Health, Detroit, MI, United States.
Frontiers in aging
|January 28, 2026
概括
癌症幸存者经历加速的生物衰老,增加死亡风险. 现型年龄加速部分调解了癌症史和死亡之间的联系,强调了需要管理幸存者的衰老.
科学领域:
- 老年学是一门学科.
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 与没有癌症的同龄人相比,癌症幸存者经常表现出加速的生物衰老.
- 了解癌症幸存者的生物衰老和死亡率之间的联系对于改善长期健康结果至关重要.
研究的目的:
- 研究癌症幸存者的生物衰老和死亡率 (因任何原因,癌症,心血管疾病) 的临床测量之间的关联.
- 检查生物衰老是否调解了癌症史和死亡风险之间的关系.
主要方法:
- 利用了国家健康和营养检查调查 (NHANES) 数据 (1999-2010年) 和死亡率跟踪到2019年.
- 包括1493名癌症幸存者和4479名匹配的非癌症患者 (年龄≥20岁).
- 根据九个生物标志物,使用表型年龄 (PhenoAge) 评估生物年龄;采用Cox回归和结构方程模型与引导分析调解效应.
主要成果:
- 与非癌症患者相比,癌症幸存者表现出加速的PhenoAge.
- PhenoAge加速部分调解了癌症史和全因死亡率之间的关联 (HRIE = 1.02).
- 加快的PhenoAge也部分调解了癌症史与癌症特定死亡率的联系 (HRIE = 1.06),分别占这些关联的15.5%和24.1%.
结论:
- 生物衰老,特别是PhenoAge加速,在癌症史和死亡率之间的关系中发挥着重要的调解作用.
- 旨在减缓生物衰老的干预措施可以提高癌症幸存者的生存率和长期健康.
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