切除第一阶段肺腺癌的长期预后与放射性,区域性和组织病理学相关性
Abdelmohaymin Abdalla1, Srinivasan Rajagopalan2, Tobias Peikert3
1Division of Pulmonary and Department of Critical Care Medicine, Mayo Clinic, Phoenix, AZ.
CHEST pulmonary
|January 28, 2026
概括
放射学可以预测切除第一阶段肺腺癌的患者的长期结果. 结节的位置会影响入侵性,但不会影响手术后的生存结果.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 机器学习 机器学习
背景情况:
- 肺腺癌 (AC) 诊断涉及复杂的决策,如观察,活检或手术.
- 机器学习,特别是放射学,可以帮助预测瘤入侵和患者存活率.
- 放射学模型,如肺癌侵略性指标得分,正在发展以改善预后.
研究的目的:
- 确定放射学是否可以预测手术切除后I期肺腺癌患者的长期结果.
- 探索第一阶段AC结节的地理位置与局部入侵或长期结果之间的相关性.
主要方法:
- 一组196名患有早期AC的患者接受了治愈切除,被跟踪了12年的中位数.
- 卡普兰-梅尔分析根据结节的放射性分类来评估无病生存率.
- 放射学和组织病理学评估了局部瘤入侵,并探索了与结节地理位置的相关性.
主要成果:
- 与"中等"或"好"分类相比,I阶段AC结节的放射学分类为"差"预测的长期预后更差 (>5年).
- 低肺部区域的AC结节显示出比上肺部结节更高的侵入性,这得到了放射学和组织病理学证实.
- 尽管侵袭性更高,但上叶结节在切除后并没有显示出无病生存优势.
结论:
- 放射学是一个有价值的工具,用于预测长期结果的患者切除I期肺腺癌.
- 肺腺癌结节的地理位置与侵袭性相关,根据放射学和组织病理学检测.
相关概念视频
Regional Terms
15.4K
Regional terms describe anatomy by dividing the body parts into different regions that contain structures involved in contributing similar functions. Using these terms helps increase the accurate description and identification of the particular region of interest or region affected by the disease.
Primarily, the human body has two major regions, the axial and appendicular regions. The axial region comprises regions from the head to the abdomen and makes up the central body axis. In contrast,...
Primarily, the human body has two major regions, the axial and appendicular regions. The axial region comprises regions from the head to the abdomen and makes up the central body axis. In contrast,...
15.4K
Piaget's Stage 1 of Cognitive Development
1.7K
The sensorimotor stage, the initial phase of Jean Piaget's theory of cognitive development, spans the first two years of a child's life. During this period, infants actively engage with their surroundings, building cognitive awareness through direct interaction with the world. This interaction is primarily based on sensory perception and motor actions, allowing infants to gradually understand basic physical properties and predict how objects interact within their environment.
Exploration...
Exploration...
1.7K
Correlations
35.8K
Correlation means that there is a relationship between two or more variables (such as ice cream consumption and crime), but this relationship does not necessarily imply cause and effect. When two variables are correlated, it simply means that as one variable changes, so does the other. We can measure correlation by calculating a statistic known as a correlation coefficient. A correlation coefficient is a number from -1 to +1 that indicates the strength and direction of the relationship between...
35.8K
Correlation and Causation
42.4K
Statistical tests can calculate whether there is a relationship, or correlation, between independent and dependent variables. An indirect relationship of the variables signifies a correlation, while a direct relationship shows causation. If it is determined that no connection exists between the variables, then the correlation is a coincidence.
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
42.4K
Correlation
15.1K
In statistics, two variables are said to be correlated if the values of one variable are associated with the other variable. Depending on the relationship between two variables, correlation can be of three types– positive correlation, negative correlation, and zero correlation.
Two variables, for example, a and b, are said to be positively correlated if both variables move in the same direction. In other words, a positive correlation exists between two variables, a and b, if:
Two variables, for example, a and b, are said to be positively correlated if both variables move in the same direction. In other words, a positive correlation exists between two variables, a and b, if:
15.1K
Long-term Depression
33.2K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.2K


