优化,热氧化稳定性,和生物活动的维生素E-奇托桑-TPP纳米配方的维生素E-奇托桑-TPP纳米配方
Hussein M Ali1, Mohamed H Attia1, Wael Mamdouh2
1Agricultural Biochemistry Department, Faculty of Agriculture, Ain-Shams University P. O. Box 68, Hadayek Shoubra Cairo 11241 Egypt Hussein_galaleldeen@agr.asu.edu.eg mohamed_aboudoma@agr.asu.edu.eg emannasreldeen@agr.asu.edu.eg.
RSC advances
|January 28, 2026
概括
奇托桑纳米乳液显著提高阿尔法-托科菲罗尔 (α-TQ) 的稳定性和抗氧化活性,提高其在食品和药品中的有效性. 这种稳定的纳米配方显示出作为食补充剂或食品添加剂的前景.
科学领域:
- 生物材料科学 生物材料科学
- 食品科学 食品科学 食品科学
- 制药科学 制药科学
背景情况:
- 阿尔法-托科菲罗尔 (α-TQ) 是重要的,但不稳定的,经常被其不那么活跃的酸盐形式 (α-TQA) 取代.
- 封装为各种应用提供了一种解决方案,以提高生物活性化合物的稳定性.
研究的目的:
- 使用响应表面方法 (RSM) 优化素 (CS) α-TQ纳米乳液 (α-TQ/CS-TPP/NE) 制备.
- 评估α-TQ纳米配方的增强稳定性,抗氧化活性和应用潜力.
主要方法:
- 响应表面方法 (RSM) 用于纳米乳液优化.
- 使用IR,TEM和热分析进行表征.
- 对H2O2和HOCl的稳定性,抗氧化活性 (DPPH,基) 和油稳定性的评估.
主要成果:
- 优化的纳米乳液实现了278.1nm的颗粒大小.
- 纳米配方显示>99%的热和氧化稳定性,优于α-TQ和α-TQA.
- 增强抗氧化活性和显著的油稳定 (>85%的氧化减少).
- 证明了对MCF-7乳腺癌细胞的增强抗癌活性.
结论:
- 素纳米乳液显著改善α-TQ的热氧化稳定性和抗氧化性质.
- 该纳米配方有效稳定食用油,并显示出抗癌应用的潜力.
- α-TQ/CS-TPP/NE对于食补充剂和食品添加剂来说是一个有价值的选择.
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