适应pH值的氨酸-Co-Poly (?? 烯酸) 水凝支架,用于修改释放梅沙胺;特征和生物安全性评估
Huma Liaqat1, Muhammad Usman Minhas2, Syed Faisal Badshah3
1Faculty of Pharmacy, The University of Lahore Lahore Pakistan pharmacisthuma123@gmail.com kashif.barkat@pharm.uol.edu.pk.
RSC advances
|January 28, 2026
概括
这项研究开发了pH敏感的水凝,用于控制的梅萨拉胺释放. 水凝显示在肠道条件中药物释放的增强,为向药物输送提供了潜在的潜力.
科学领域:
- 材料科学 材料科学 材料科学
- 聚合物化学 聚合物化学
- 制药科学 制药科学
背景情况:
- 控制的药物输送系统旨在优化治疗疗效和患者的遵守.
- 对pH敏感的水凝提供特定部位的药物释放,响应生理pH的变化.
- 梅萨拉用于治疗炎症性肠病,需要有针对性的输送到肠道.
研究的目的:
- 开发和表征pH敏感的水凝,用于控制释放梅萨拉胺.
- 在模拟的胃和肠道条件下评估水凝的性能.
- 研究配方成分对水凝特性和药物释放的影响.
主要方法:
- 使用自由基聚合来合成pH敏感的水凝.
- 水凝的特征包括富里埃变换红外光谱 (FTIR),热重力测量分析 (TGA) 和扫描电子显微镜 (SEM).
- 在pH 1.2和pH 7.4.4的缓冲溶液中,在37°C进行了胀行为和梅沙胺释放研究.
主要成果:
- FTIR证实了成功的聚合物网络形成和药物纳入.
- 与未经修改的聚合物相比,TGA表明水凝的热稳定性得到了改善.
- SEM揭示了一个多孔的表面结构. 与pH 1.2相比,pH 7.4时观察到明显更高的胀比率和药物释放率.
- 高度的氨酸和烯酸增加了多孔性,胀,药物加载和释放率.
结论:
- 开发的水凝表现出pH响应性行为,有利于在肠道条件下增强药物释放.
- 该配方显示出作为有效载体的潜力,用于pH响应的,局部特定的梅沙的输送.
- 这项研究有助于在设计定制水凝,用于精密医学和药物释放控制应用方面取得进展.
相关概念视频
Amino acids
105.2K
Amino acids are the monomers that comprise proteins. Each amino acid has the same fundamental structure, which consists of a central carbon atom, or the alpha (α) carbon, bonded to an amino group (NH2), a carboxyl group (COOH), and to a hydrogen atom. Every amino acid also has another atom or group of atoms bonded to the central atom known as the R group. There are 20 common amino acids present in proteins, each with a different R group. Variation in the amino acid sequence is responsible for...
105.2K
Polyprotic Acids
31.9K
Acids are classified by the number of protons per molecule that they can give up in a reaction. Acids such as HCl, HNO3, and HCN that contain one ionizable hydrogen atom in each molecule are called monoprotic acids. Their reactions with water are:
31.9K
Mixtures of Acids
21.7K
The pH of a solution containing an acid can be determined using its acid dissociation constant and its initial concentration. If a solution contains two different acids, then its pH can be determined using one of several methods depending upon the relative strength of the acids and their dissociation constants.
A Mixture of a Strong Acid and a Weak Acid
In a mixture of a strong acid and a weak acid, the strong acid dissociates completely and becomes a source of almost all the hydronium ions...
A Mixture of a Strong Acid and a Weak Acid
In a mixture of a strong acid and a weak acid, the strong acid dissociates completely and becomes a source of almost all the hydronium ions...
21.7K
Nucleic Acids
50.1K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
50.1K
Nucleic acids
189.4K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
189.4K
Acidity of Carboxylic Acids
8.7K
Carboxylic acids are the strongest organic acids. However, their acidic strength is much less than mineral acids like HCl. Carboxylic acids ionize in water and readily lose the hydroxyl proton to form a resonance-stabilized carboxylate ion.
8.7K


