相关实验视频
Updated: Jan 29, 2026

05:44
Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
2.1K
含有微小化纯化黄粉碎片自发分解后的颗粒度分析 (SIZE研究)
João Vitor Santana da Silva1, Adriane Dos Santos Francisco1, Isabella Mourão Machado Valle1
1Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BRA.
Cureus
|January 28, 2026
概括
迪奥斯/赫斯佩里丁微化 (MPFF) 影响药物吸收. 该SIZE研究发现了制造商之间显著的颗粒大小差异,影响治疗疗效,并强调了需要标准化的需要.
科学领域:
- 药理学 药理学是指药理学的学科.
- 制药科学 制药科学
- 药物运输 药物运输 药物运输
背景情况:
- 含有迪奥斯和赫斯佩里丁的微化纯化黄粉碎片 (MPFF) 治疗慢性静脉不全.
- 微化改善了迪奥斯的溶解性和生物可用性,提高了治疗效果.
- 制造商之间的微缩工艺的变化可能会影响药物的疗效.
研究的目的:
- 为了评估MPFF片 (900/100毫克迪奥斯/赫斯佩里丁) 的颗粒大小分布.
- 为了比较来自巴西四家制药厂商的MPFF产品.
主要方法:
- 使用自发分解方法模拟溶解.
- 通过光学显微镜和图像分析进行颗粒度分析.
- 在分解后5分钟和15分钟的粒子大小分类.
主要成果:
- 在制造商之间观察到颗粒大小分布的显著差异.
- 参考产品呈现出较高的细颗粒百分比 (1-5μm范围).
- 更细的颗粒大小与潜在的更快溶解和更好的吸收有关.
结论:
- 颗粒大小对于药物的溶解性和生物可用性至关重要.
- 微化工艺的差异直接影响MPFF的治疗疗效.
- 微缩的标准化法规对于确保产品质量和有效性的一致性至关重要.
相关概念视频
Spontaneity
29.7K
A spontaneous process is one that occurs naturally under certain conditions. A nonspontaneous process, on the other hand, will not take place unless it is “driven” by the continual input of energy from an external source. Processes have a natural tendency to occur in one direction under a given set of conditions. Water will naturally flow downhill (spontaneous process), but uphill flow (nonspontaneous process) requires outside intervention such as the use of a pump. Iron exposed to...
29.7K
Spontaneous and Induced Mutations
2.2K
Spontaneous mutations arise infrequently during DNA replication due to errors in the process. A key factor behind these errors is tautomeric shifts in nitrogenous bases, where bases transition from keto to enol forms or amino to imino forms. This shift can alter base-pairing rules, leading to mutations. Additionally, reactive oxygen species (ROS) arising from aerobic metabolism can damage DNA, resulting in depurination (loss of a purine base) or depyrimidination (loss of a pyrimidine base).
2.2K
Cell Size
127.1K
Cell sizes vary widely among and within organisms. Bacterial cells range between 1-10 micrometers (μm)and are considerably smaller than most eukaryotic cells. The smallest bacteria are 0.1 μm in diameter—about a thousand times smaller than eukaryotic cells, which typically range from 10-100 μm.
Surface Area
Cells can take in nutrients and water via diffusion through the plasma membrane itself or through specific channels in the membrane. The area of the membrane surrounding...
Surface Area
Cells can take in nutrients and water via diffusion through the plasma membrane itself or through specific channels in the membrane. The area of the membrane surrounding...
127.1K
Partial Fractions
215
A partial fraction is a component of a rational expression represented as the sum of simpler fractions. When a rational function is expressed as a ratio of two polynomials, it can often be decomposed into a sum of fractions whose denominators are simpler polynomials, typically linear or irreducible quadratic factors. This process is called partial fraction decomposition, and it is used to simplify complex expressions for integration, solving equations, or analysis.Partial fraction decomposition...
215
Subcellular Fractionation
8.9K
The homogenate obtained after cell lysis contains various membrane-bound organelles that can be further separated into pure fractions by subcellular fractionation. These isolates are used to study specific cellular components, analyze localized protein activity, and are even employed in diagnostics. Fractionation is typically achieved using centrifugation methods, the most common being density-gradient and differential centrifugation.
Differential Centrifugation
Differential centrifugation is...
Differential Centrifugation
Differential centrifugation is...
8.9K
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules
320
Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
320

