在Beta-thalassemia重症患者内分泌系统的功能异常:来自医院的观察性研究的见解
Upendra Prasad Sahu1, Yuthika Kumari1, Neha Rani1
1Department of Pediatrics, Rajendra Institute of Medical Sciences, Ranchi, IND.
Cureus
|January 28, 2026
概括
患有β-thalassemia major的儿童面临高水平的内分泌问题,如糖尿病和由于铁过载和输血导致的生长问题. 早期查和更好的治疗对于管理这些并发症至关重要.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 血液学 血液学 血液学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 儿童的大型β-thalassemia (BTM) 往往导致内分泌并发症.
- 铁过载和频繁的输血是这些问题的主要驱动因素.
研究的目的:
- 确定多次输血儿科BTM患者内分泌功能障碍的患病率,模式和危险因素.
主要方法:
- 在RIMS,Ranchi的100名儿科BTM患者 (2-14岁) 的横截面研究.
- 分析包括临床数据,输血史,人体测量和内分泌/代谢实验室测试 (HbA1c,甲状腺,费里丁等). ) 的情况.
- 使用SPSS v26的统计分析;p ≤0.05是显著的.
主要成果:
- 内分泌系统疾病的高患病率:糖尿病 (14.6%),生长激素缺乏 (11.2%),甲状腺功能低下 (9.8%),甲状腺功能低下 (6.3%).
- 较高的HbA1c水平与糖尿病,甲状腺功能低下和GHD相关.
- 铁过载,频繁的输血和年龄较大 (>10岁) 预测内分泌功能障碍;化疗显示出有限的保护作用.
结论:
- 多次输血BTM的患者具有显著的内分泌异常风险.
- 定期内分泌查,优化化和量身定制的输血协议至关重要.
- 多学科护理对于改善BTM患者的治疗结果至关重要.
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