补充和替代药物诱导的联合肝毒性:一个案例报告
George S Zacharia1, Vedashree Ravte1, Abhilasha Jyala2
1Internal Medicine, BronxCare Health System, New York, USA.
Cureus
|January 28, 2026
概括
补充和替代医学 (CAM) 的使用导致严重的肝脏和脏损伤在一个病人自我治疗脂肪肝. 临床医生必须意识到CAM相关的药物诱导性肝损伤 (DILI) 风险.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学是指药理学的学科.
背景情况:
- 药物诱导性肝损伤 (DILI) 是一个重要的全球健康问题.
- 补充和替代医学 (CAM) 的使用正在增加,但往往缺乏严格的安全性和有效性数据.
- CAM产品经常用于肝脏疾病,这可能会带来潜在的风险.
研究的目的:
- 报告CAM使用后出现的严重肝功能障碍病例.
- 为了突出特定CAM成分的潜在肝毒性.
- 强调临床医生的意识和患者对CAM风险的教育的重要性.
主要方法:
- 一个42岁的男性患有脂肪肝,接受CAM治疗的病例报告.
- 排除肝脏和功能障碍的其他原因 (病毒性,自身免疫性,代谢性,阻塞性).
- 使用罗塞尔·乌克拉夫因果关系评估方法 (RUCAM) 的因果关系评估.
主要成果:
- 患者在用CAM自我治疗后出现严重的肝脏和功能障碍.
- RUCAM评分表明CAM和DILI (肝细胞模式) 之间可能存在因果关系.
- 疑似的CAM成分包括 *Carica papaya*, *Alstonia boonei* 和 *Tetrapleura tetraptera*. 这两种类型的植物是最常见的.
结论:
- 使用CAM可以导致药物诱导的严重肝损伤和功能障碍.
- 对于医疗保健提供者来说,对草药产品风险的警和患者教育至关重要.
- 早期识别和停止违规代理,以及支持性护理,可以改善结果.
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