桥梁科学和课程:准备计算毒理学的未来领导者
Frances Hall1, Candice Johnson1
1Instem, Stone, United Kingdom.
Frontiers in toxicology
|January 28, 2026
概括
本研究概述了计算毒理学的基本技能和教育框架,重点是 (定量) 结构-活性关系 ((Q) SAR) 和化学安全评估的交叉阅读方法.
科学领域:
- 计算毒理学计算毒理学
- 化学安全评估 化学安全评估
- 监管科学是一种监管科学.
背景情况:
- 计算毒理学对于化学安全,药物发现和危险识别至关重要.
- 现有的框架,如 (Q) SAR评估框架 (QAF) 和经合组织验证原则指导方法的应用.
- 监管素养是评估 (定量) 结构-活动关系 ((Q) SAR) 和横读方法的关键.
研究的目的:
- 为计算毒理学定义基础技能,技术能力和监管素养.
- 在 (Q) SAR和阅读中介绍基于能力的学习的教育框架.
- 探索教育环境的监管用例,强调使用上下文.
主要方法:
- 建议的基本技能和技术能力的概述.
- 理论知识与实践经验的整合 (实习,案例研究).
- 基于能力的教育框架的开发,具有跨学科的曝光.
主要成果:
- 一个教育框架从基础知识发展到方法理解和可靠性评估.
- 专注于监管的用例凸显了在各种应用中需要基本原则的需要.
- 强调使用上下文驱动的课程设计和体验式学习.
结论:
- 有效地应用 (Q) SAR和交叉阅读需要具备特定的技能和监管素养.
- 基于能力的跨学科教育框架支持实际应用和可靠性评估.
- 经验式学习和协作举措对于推进计算毒理学教育至关重要.
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