冠心病患者炎症指数升高和未来中风风险:多中心前性队列研究
Jie Cheng1, Keli Li2, Meng Chen3
1Department of Cardiology II and Geriatric Management Ward, Zhangye Second People's Hospital, Zhangye, China.
Frontiers in cardiovascular medicine
|January 28, 2026
概括
炎症增加了冠心病 (CHD) 患者中风风险. 系统性炎症综合指数 (AISI) 最好预测这种风险,有助于早期监测.
科学领域:
- 心脏病学 心脏病学
- 炎症研究 炎症研究
- 预防中风 预防中风
背景情况:
- 冠心病 (CHD) 患者的中风风险更高.
- 炎症是导致这种风险增加的一个关键因素.
- 新出现的炎症标志物需要调查,以预测心脏病中风风险.
研究的目的:
- 调查三种炎症标志物与心脏病患者中风风险之间的关联.
- 为了确定临床上最有价值的炎症标志物用于中风风险预测.
- 探索标志物和中风风险之间的潜在剂量反应关系.
主要方法:
- 对5,289名心血管疾病患者的COX回归分析.
- 系统性炎症反应指数 (SIRI),系统性免疫炎症指数 (SII) 和系统性炎症总指数 (AISI) 的评估.
- 卡普兰-梅尔曲线,受限立方线和ROC分析用于风险和预测性绩效评估.
主要成果:
- 这三种炎症标志物 (SIRI,SII,AISI) 都与中风风险增加有显著的相关性.
- 较高的炎症水平与较高的中风发病率相对应.
- 与SII和SIRI相比,AISI表现出优越的预测性能.
结论:
- SIRI,SII和AISI与心脏病中风风险增加有关.
- 在心脏病患者中,AISI为中风风险提供了优越的预测价值.
- AISI可以作为一种工具,用于早期中风风险监测和评估心脏病.
相关概念视频
Inflammatory Bowel Disease II: Crohn's Disease
1.0K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.0K
Coronary Artery Disease I: Introduction
1.1K
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.1K
Coronary Artery Disease II: Pathophysiology
420
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
420
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
570
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
570
Inflammatory Bowel Disease I: Ulcerative Colitis
962
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
962
Inflammatory Bowel Disease V: Surgical Management
493
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
493


