释放免疫疗法在可切除非小细胞肺癌患者的潜力
Sandip Pravin Patel1, Justin Gainor2, Steven Kao3
1UC San Diego Moores Cancer Center, San Diego, CA, United States.
Frontiers in oncology
|January 28, 2026
概括
免疫疗法对可切除的非小细胞肺癌 (NSCLC) 是有前途的. 本综述评估了可切除NSCLC免疫治疗的最佳时间和预测因素,以指导临床决策.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 胸部外科手术 胸部外科手术
背景情况:
- 免疫疗法已在晚期非小细胞肺癌 (NSCLC) 中表现出有效性.
- 越来越多的趋势是,在可切除的NSCLC的早期阶段应用免疫疗法,包括局部晚期的瘤基因驱动负性疾病.
- 八个III期试验证实了 (化疗) 免疫疗法在可切除的NSCLC中在辅助,新辅助和外科外科设置中的好处.
研究的目的:
- 审查当前关于可切除NSCLC免疫治疗的数据.
- 根据疾病阶段,评估免疫治疗的最佳时间 (新辅助,术后,辅助).
- 确定关键的预测因素和响应评估,用于患者选择和治疗降级/升级.
主要方法:
- 对III期临床试验和当前文献进行系统审查.
- 对治疗指南和专家共识的分析.
- 预测生物标志物和响应评估工具的评估.
主要成果:
- 有多种免疫疗法方案可供使用,并且正在研究可切除的NSCLC.
- 免疫治疗的最佳时间仍然是一个关键问题,临床指导方针各不相同.
- 预测因素和反应评估至关重要,但需要进一步澄清个性化治疗选择.
结论:
- 免疫疗法在可切除的NSCLC中越来越多地被使用,这需要一个多学科的方法来实现最佳的治疗时间和患者选择.
- 需要进一步的研究来完善预测生物标志物和响应评估的作用,以指导个性化免疫疗法策略.
- 证据支持免疫疗法在可切除的NSCLC中的好处,但关于最佳应用的共识正在演变.
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