预测KELIM在高级卵巢癌患者的新辅助治疗中的预测价值
Yicong Wang1, Yongai Yu1, He Yuan1
1Department of Gynecology and Obstetrics, Central Hospital of Dalian University of Technology, Dalian Municipal Central Hospital, Dalian, China.
Frontiers in oncology
|January 28, 2026
概括
CA-125消除速率常数 (KELIM) 有效地预测了接受新辅助化疗和间隔脱皮手术的晚期卵巢癌患者的手术结果和生存率. 较高的KELIM表明更好的预后和较低的抗性风险.
科学领域:
- 妇科瘤学 妇科瘤学
- 医学生物标志物 医学生物标志物
- 化疗和外科瘤学的化学治疗.
背景情况:
- 先进的卵巢癌治疗往往涉及新辅助化疗,其次是间隔除手术 (NACT-IDS).
- 在这种情况下,预测手术成功和患者的结果仍然是一个临床挑战.
- CA-125的动力学,特别是消除速率常数 (KELIM),正在作为潜在的预测生物标志物进行研究.
研究的目的:
- 评估CA-125消除速率常数 (KELIM) 在晚期卵巢癌患者的预测意义.
- 评估KELIM在预测间隔除手术 (IDS) 中令人满意的细胞减少中的作用.
- 确定KELIM与NACT-IDS后的生存预后和基化学敏感性的关联.
主要方法:
- 从70名接受NACT-IDS的晚期卵巢癌患者的临床数据的回顾性分析.
- 在新辅助化疗期间使用验证的在线工具计算CA-125消除速率常数 (KELIM).
- 统计分析以将KELIM与IDS手术结果,无进展生存 (PFS),总生存 (OS) 和抗复发 (PRR) 相关联.
主要成果:
- 较高的KELIM与在IDS (1.40对0.61,P<0.05) 达到令人满意的脱的可能性更高显著相关.
- 凯利姆和IDS手术结果是PFS和OS的独立预测因素;KELIM≥1的患者的PFS (26个月与18个月) 和OS (39个月与28个月) 显著更长.
- 凯利姆≥1是一个独立的保护因子,防止白金耐药性复发 (PRR),在白金敏感组的凯利姆较高 (1.30对0.73,P<0.05).
结论:
- CA-125清除速率常数 (KELIM) 是预测NACT-IDS接受的晚期卵巢癌患者的结果的一个有价值的参数.
- 除了IDS手术结果之外,KELIM可以独立预测患者的预后和抗性风险.
- 患有高KELIM的患者表现出较低的白金耐药性复发风险,即使在IDS期间的亚最佳细胞减少.
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