基于OCT进行放射治疗的头癌患者的光盘参数变化的评估
Rui Liu1, Pengfei Chen1, Keren Zhao1
1Department of Ophthalmology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Frontiers in oncology
|January 28, 2026
概括
头部和部放射治疗可以改变光盘结构,影响胆道微循环和视网膜厚度. 光学连贯断层扫描 (OCT) 有助于早期检测这些与辐射有关的眼部并发症.
科学领域:
- 眼科医生 眼科 眼科
- 辐射瘤学 辐射瘤学
- 医疗成像医学成像
背景情况:
- 头部和部放射治疗对于治疗瘤至关重要,但可能导致眼部并发症,如视神经病变.
- 光盘是评估辐射引起的眼损伤的关键指标.
- 光学连贯断层扫描 (OCT) 提供了详细的视网膜和光盘结构信息,用于早期检测微妙的变化.
研究的目的:
- 通过使用OCT来研究头部和部放射治疗后光盘的结构变化.
- 评估放射治疗对视网膜神经纤维层厚度 (RNFL) 和胆道血管指数 (CVI) 的影响.
主要方法:
- 一项前性横截面研究,涉及60名健康人群和60名头癌患者.
- 在放射治疗前,放射治疗后以及随访3个月和6个月后进行了OCT检查.
- 测量包括RNFL厚度和CVI;使用曼·惠特尼U和t测试进行统计分析.
主要成果:
- 放射治疗在治疗后3个月和6个月显著影响了黄斑厚度和降低了冠状血管指数 (CVI).
- 在放射治疗后,侧鼻斑块厚度显著减小 (P<0.001).
- 视网膜神经纤维层 (RNFL) 显示出显著的区域变化,特别是6个月后的内鼻和内下部RNFL (P=0.0109,P=0.0187).
结论:
- 头部和部放射疗法诱导显著的光盘结构变化,特别是影响胆道微循环和视网膜区域.
- OCT对于早期检测这些辐射诱导的眼部变化非常有价值,使得及时的临床干预成为可能.
- 需要进一步的研究来探索放射治疗对光盘功能的影响,并评估干预措施.
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