构建和验证一种预测模型,用于甲状腺癌的内镜甲状腺切除术期间的低温并发症
1Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Frontiers in molecular biosciences
|January 28, 2026
概括
这项研究开发了一种临床预测模型,用于在内镜甲状腺癌手术期间识别患有术后低温风险的患者. 该模型准确预测风险,帮助手术室护士在患者护理中.
科学领域:
- 麻醉学 麻醉学
- 手术瘤学手术瘤学
- 临床预测建模模型
背景情况:
- 术内低温是手术期间常见的并发症,会对患者的治疗结果产生负面影响.
- 甲状腺癌的内镜甲状腺切除术在温度调节方面提出了独特的挑战.
- 识别有风险的患者对于主动管理和改善外科安全至关重要.
研究的目的:
- 开发和验证一个临床预测模型,用于手术期间低温风险.
- 在接受内镜甲状腺切除术的患者中确定手术内低温的独立预测因子.
- 评估模型的预测准确性和临床实用性.
主要方法:
- 用单变量和多变量逻辑回归分析来确定风险因素.
- 使用独立预测器构建了一个名ogram模型.
- 用ROC曲线,校准图和决策曲线分析 (DCA) 评估模型性能.
- 进行了外部验证,以评估可概括性.
主要成果:
- 输液量和灌液温度是低温的独立风险因素.
- 身体质量指数 (BMI) 被确定为一个独立的保护因素.
- 该模型显示出出色的预测准确性 (AUC = 0.945) 和外部验证的临床实用性 (AUC = 0.831).
结论:
- 开发的诺莫格拉姆模型是预测手术内低温风险的宝贵工具.
- 该模型显示了强大的预测性能和在内镜甲状腺癌手术中的临床实用性.
- 这个工具可以帮助手术室护士识别高风险患者进行有针对性的干预.
相关概念视频
Reliability and Validity
13.9K
Reliability and validity are two important considerations that must be made with any type of data collection. Reliability refers to the ability to consistently produce a given result. In the context of psychological research, this would mean that any instruments or tools used to collect data do so in consistent, reproducible ways.
13.9K
The Thyroid Gland
7.6K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
7.6K
Predicting Molecular Geometry
45.7K
VSEPR Theory for Determination of Electron Pair Geometries
45.7K
Hemodialysis II: Procedure and Complications
779
DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
779
Functions of Thyroid Hormones
5.6K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
5.6K
Prediction Intervals
3.4K
The interval estimate of any variable is known as the prediction interval. It helps decide if a point estimate is dependable.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y.
3.4K


