癌症诊断和预后中的液体活检:精确瘤学的范式转变
Rayane da Silva Abreu1, Danielle Dias Pinto Ferreira1,2, Natassia Silva de Araujo1
1Laboratory of Applied Genomics and Bioinovations, IOC, Fiocruz, Rio de Janeiro, Brazil.
Frontiers in molecular biosciences
|January 28, 2026
概括
液体活检提供了一种使用循环生物标志物检测和监测癌症的不那么侵入性的方法. 这种方法有助于个性化治疗和早期检测,改变了瘤学护理.
科学领域:
- 在瘤学瘤学.
- 分子诊断学 分子诊断
- 生物化学 生物化学
背景情况:
- 传统的组织活检是侵入性的,容易产生采样错误.
- 液体活检通过生物流体中的循环生物标志物提供实时瘤洞察力.
- 进步对于改善癌症检测和管理至关重要.
研究的目的:
- 审查液体活检技术和应用的最新进展.
- 要突出关键的生物标志物,如循环瘤细胞 (CTC) 和循环瘤DNA (ctDNA).
- 讨论精密瘤学的方法和临床实用性.
主要方法:
- 关于液体活检生物标志物和技术的当前文献的综述.
- 专注于循环瘤细胞 (CTC),循环瘤DNA (ctDNA),非编码RNA,细胞外囊泡和蛋白质.
- 探索下一代测序,数字PCR,微流体学,蛋白质学和人工智能等技术.
主要成果:
- 液体活检生物标志物为早期诊断,预后和监测治疗反应提供了洞察力.
- 最先进的方法提高了测试的灵敏度,特异性和可扩展性.
- 临床研究显示了定制治疗和早期复发检测的潜力.
结论:
- 液体活检是瘤学的范式转变,使得动态和个性化的癌症管理成为可能.
- 它有望改善患者的治疗结果,并推进精准医学.
- 解决全球获取差异对于公平实施至关重要.
相关概念视频
Uncertainty in Measurement: Accuracy and Precision
100.9K
Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value.
100.9K
Nursing Diagnosis
4.0K
Following assessment, a nursing diagnosis is the next step in the nursing process. It begins after the nurse has collected and recorded the patient data. The purpose of diagnosing is to identify how the client responds to actual or potential health processes, identify factors that bestow or that cause health problems, the etiologies, and identify resources or strengths the individual, group, or community can draw on to prevent or resolve problems.
The nursing diagnosis focuses on evidence-based...
The nursing diagnosis focuses on evidence-based...
4.0K
Accuracy and Precision
15.2K
Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value. Highly accurate...
15.2K
Formulating and Validating Nursing Diagnosis I
3.8K
A nursing diagnosis is written when the nurse recognizes a cluster of essential patient data indicating health problems treated with independent nursing interventions. The standardized terminologies of a nursing diagnosis help nurses identify and treat patients' problems. Every electronic health record that uses nursing diagnosis must employ standard diagnostic terminology. Developing an efficient, individualized care plan begins with accurate nursing diagnoses.
There are thirteen domains...
There are thirteen domains...
3.8K
Documentation of Nursing Diagnosis
1.8K
The nurse documents nursing diagnoses and enters them into the patient record. The identified patient's nursing diagnosis is either written out with a plan of care or entered into the electronic health record.
In some settings, data-driven computerized decision support systems are in place, allowing for more accurate nursing diagnoses. The database within one of these systems includes diagnostic labels defining characteristics, activities, and indicators for nursing. A nurse enters...
In some settings, data-driven computerized decision support systems are in place, allowing for more accurate nursing diagnoses. The database within one of these systems includes diagnostic labels defining characteristics, activities, and indicators for nursing. A nurse enters...
1.8K
The Precise Definition of a Limit
290
Understanding the formal definition of a limit is essential for precise mathematical analysis. This concept allows us to rigorously determine how a function behaves near a particular point without relying on ambiguous notions such as "getting close." The ε-δ definition plays a foundational role in calculus, ensuring analytical clarity and logical consistency in limit evaluation.The formal definition states that the limit of a function f(x) as x approaches a is L, written asif for...
290


