Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

RNA-seq03:21

RNA-seq

12.0K
RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
12.0K
DNA Packaging00:58

DNA Packaging

112.3K
Overview
112.3K
Chromatin Packaging01:32

Chromatin Packaging

19.2K
Each human somatic cell contains 6 billion base pairs of DNA. Each base pair is 0.34 nm long, meaning each diploid cell contains a staggering 2 meters of DNA. This long DNA strand is packed inside a nucleus measuring only 10-20 microns in diameter with the help of specialized DNA-binding proteins called histones. Together they form a compact DNA-protein complex called chromatin. The chromatin is further compacted into higher-order structures. The highest level of compaction is achieved during...
19.2K
Chromatin Packaging02:21

Chromatin Packaging

22.1K
Each human somatic cell contains 6 billion base-pairs of DNA. Each base-pair is 0.34 nm long, which means that each diploid cell contains a staggering 2 meters of DNA. How is such a long DNA strand packed inside a nucleus measuring only 10 - 20 microns in diameter? 
The chromatin
In combination with specialized DNA binding protein called Histones, the DNA double helix forms a compact DNA: protein complex called chromatin. The chromatin itself is further compacted into higher-order...
22.1K
Chromatin Packaging02:21

Chromatin Packaging

9.7K
9.7K
Uncertainty in Measurement: Reading Instruments02:46

Uncertainty in Measurement: Reading Instruments

51.5K
Counting is the type of measurement that is free from uncertainty, provided the number of objects being counted does not change during the process. Such measurements result in exact numbers. By counting the eggs in a carton, for instance, one can determine exactly how many eggs are there in the carton. Similarly, the numbers of defined quantities are also exact. For example, 1 foot is exactly 12 inches, 1 inch is exactly 2.54 centimeters, and 1 gram is exactly 0.001 kilograms. Quantities...
51.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Clinical and Evolutionary Aspects of CDKL5-Related Developmental Epileptic Encephalopathy: A Case Report.

Cureus·2026
Same author

Common cutaneous signs unmasking a severe hematological disorder: GATA2 deficiency.

Dermatology online journal·2026
Same author

Exome sequencing reveals new insights into the germline landscape of inflammatory breast cancer among Tunisian patients.

Journal of translational medicine·2025
Same author

Knowledge, attitudes, and practices regarding tetanus: a case of healthcare workers in the emergency and intensive care departments of a regional hospital in the northern region of Morocco.

BMC health services research·2025
Same author

Unlocking the African bioeconomy and strengthening biodiversity conservation through genomics and bioinformatics.

npj biodiversity·2025
Same author

Identification of Gene Expression Biomarkers Predictive of Latent Tuberculosis Infection Using Machine Learning Approaches.

Genes·2025

相关实验视频

Updated: Jan 29, 2026

Characterization of In Vitro Differentiation of Human Primary Keratinocytes by RNA-Seq Analysis
07:29

Characterization of In Vitro Differentiation of Human Primary Keratinocytes by RNA-Seq Analysis

Published on: May 16, 2020

6.7K

SeqExpressionAnalyser:用于自动端到端RNA-Seq分析的R包,从读取到微分表达式.

Sanae Esskhayry1,2,3, Ouafae Kaissi2, Fouzia Radouani4

  • 1Life and Health Sciences Laboratory, FMPT, Abdelmalek Essaadi University, Tetouan, Morocco.

Bioinformatics and biology insights
|January 28, 2026
PubMed
概括

SeqExpressionAnalyser是一个新的R包,简化了RNA测序 (RNA-Seq) 数据的差异基因表达分析. 这个用户友好的工具整合了整个工作流程,使R用户能够访问复杂的分析.

关键词:
在这个过程中,R是R.在RNA-Seqq.不同的表达方式,不同的表达方式.交互式数据分析 交互式数据分析网络应用程序 网络应用程序

更多相关视频

RNA-Seq Analysis of Differential Gene Expression in Electroporated Chick Embryonic Spinal Cord
11:13

RNA-Seq Analysis of Differential Gene Expression in Electroporated Chick Embryonic Spinal Cord

Published on: November 1, 2014

15.1K
Rup (RNA-seq Usability Assessment Pipeline) - Quality Control for Bulk RNA-seq Experiments in Eukaryotes
05:07

Rup (RNA-seq Usability Assessment Pipeline) - Quality Control for Bulk RNA-seq Experiments in Eukaryotes

Published on: November 7, 2025

367

相关实验视频

Last Updated: Jan 29, 2026

Characterization of In Vitro Differentiation of Human Primary Keratinocytes by RNA-Seq Analysis
07:29

Characterization of In Vitro Differentiation of Human Primary Keratinocytes by RNA-Seq Analysis

Published on: May 16, 2020

6.7K
RNA-Seq Analysis of Differential Gene Expression in Electroporated Chick Embryonic Spinal Cord
11:13

RNA-Seq Analysis of Differential Gene Expression in Electroporated Chick Embryonic Spinal Cord

Published on: November 1, 2014

15.1K
Rup (RNA-seq Usability Assessment Pipeline) - Quality Control for Bulk RNA-seq Experiments in Eukaryotes
05:07

Rup (RNA-seq Usability Assessment Pipeline) - Quality Control for Bulk RNA-seq Experiments in Eukaryotes

Published on: November 7, 2025

367

科学领域:

  • 生物信息学是一种生物信息学.
  • 计算生物学 计算生物学
  • 基因组学就是基因组学.

背景情况:

  • 对RNA测序 (RNA-Seq) 数据的差异基因表达分析对于理解生物过程和疾病至关重要.
  • 当前的工作流涉及手动组合多个工具和脚本,这耗时且不易于使用,特别是对于非专家而言.

研究的目的:

  • 开发用于RNA-Seq差异基因表达分析的综合,自动化和可访问的解决方案.
  • 为R用户提供一个用户友好的平台,统一整个R用户的分析过程.

主要方法:

  • 开发了SeqExpressionAnalyser,这是一个R包,在Shiny框架上构建了一个Web应用程序.
  • 该软件包使用户能够在FASTQ文件上进行质量控制,过,对齐,读数和微分表达式分析.

主要成果:

  • SeqExpressionAnalyser为RNA-Seq数据分析提供了一个交互式和统一的平台.
  • 该工具生成全面的输出,包括数据表,HTML报告和可视化.
  • 源代码可在GitHub上获得GPLv3许可,并提供了Docker图像.

结论:

  • SeqExpressionAnalyser解决了对RNA-Seq差异基因表达分析的可访问和自动化解决方案的需求.
  • 该套件使R用户,包括非专家,能够高效地进行复杂的分析.