在儿童器官和骨髓移植后发生的异性胃肠道疾病
Erin Sinai1, Bridget E Wilson2,3, Melissa Pecak2
1School of Medicine, Creighton University Phoenix Arizona USA.
JGH open : an open access journal of gastroenterology and hepatology
|January 28, 2026
概括
根据儿童的移植类型,性胃肠道疾病 (EGID) 的亚型因移植类型而异. 多晶体移植接受者显示出高性食道炎加上高性胃炎 (EoE+EoG) 的比率较高. 需要进一步的研究.
科学领域:
- 胃肠病学 胃肠病学
- 儿科移植医学 儿科移植医学
- 免疫学 免疫学 免疫学
背景情况:
- 在儿科肝脏和心脏移植接受者中,越来越多地发现了异性胃肠道疾病 (EGID).
- 关于其他固体器官和骨髓移植后EGID患病率的数据有限.
研究的目的:
- 调查EGID子集与各种儿科固体器官和骨髓移植类型之间的关系.
- 确定特定EGID诊断和移植方式之间的潜在关联.
主要方法:
- 对患有EGID的儿科患者和从2007年到2023年的移植史进行了单中心回顾性图表审查.
- 统计分析包括连续变量的ANOVA和分类变量的费舍尔精确测试,以比较移植组.
主要成果:
- 这项研究包括30名EGID患者,他们接受了各种移植 (肝脏,心脏,骨髓,多胞体,脏).
- 观察到异性食管炎加上异性胃炎 (EoE+EoG) 发病率的显著差异 (p=0.011),特别是在多胞体接受者中更高.
- 在移植组之间的胃食道逆流 (GER) 和口腔过敏综合征的流行率中发现了统计学上显著的差异 (p=0.036,p=0.033).
结论:
- 在儿科患者中,EGID亚型表现出根据接收的移植类型的变异性.
- 多胞胎移植接受者表现出较高的EoE+EoG发生率.
- 这些探索性发现需要进行更大规模的多中心研究,以确认关联,并在更广泛的移植受体中探索EGID.
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