治疗儿童急性腹的益生菌:一个证据综合
Cheng Chen1, Pei Liu2, Lang Xiao1
1School of Basic Medical Sciences, Chengdu Medical College, Chengdu, Sichuan, China.
Frontiers in pediatrics
|January 28, 2026
概括
益生菌有效地减少了儿童的腹持续时间和发病率,为儿科胃肠炎提供了有益的干预措施. 像Limosilactobacillus reuteri和Lacticaseibacillus rhamnosus这样的特定菌株在临床试验中显示出有希望的结果.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 微生物组研究 微生物组研究
- 基于证据的医学 基于证据的医学
背景情况:
- 急性腹是全球儿童疾病和住院的主要原因之一.
- 有效的治疗对于降低儿科发病率和死亡率至关重要.
研究的目的:
- 评估益生菌在治疗儿童急性腹方面的疗效.
- 综合来自对益生菌干预的随机临床试验的证据.
主要方法:
- 对25项涉及9,071名儿童的随机对照试验 (RCT) 的系统综述和元分析.
- 搜索的主要数据库 (EMBASE,PubMed,Cochrane) 至2023年9月.
- 分析了包括腹持续时间,康复率和住院时间在内的结果.
主要成果:
- 益生菌显著缩短了大约1.21天的腹持续时间 (SMD=-0.44).
- 减少了腹病例的数量 (RR=0.68) 和便的频率 (SMD=-0.38).
- 乳酸菌株显示出特定的好处,其中Limosilactobacillus reuteri减少了持续时间,而Lacticaseibacillus rhamnosus减少了病例数.
结论:
- 益生菌在治疗儿科腹方面表现出临床疗效.
- 他们缩短了疾病的持续时间,增加了恢复,并减少了腹的发生率.
- 进一步的研究可能会改进针对菌株的建议,以获得最佳的结果.
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