红细胞输血量对CRS预后的影响:一种倾向匹配的研究
Jie Li1, Youzhong Xing1, Wenwen Chen2
1Department of Blood Transfusion, Central Hospital Affiliated to Shandong First Medical University, Jinan, China.
Frontiers in surgery
|January 28, 2026
概括
在细胞还原性手术 (CRS) 与高热性腹腔内化疗 (HIPEC) 期间输入大量手术内红细胞 (RBC) 可能会使长期生存情况恶化. 对于接受CRS/HIPEC的患者,建议采用限制性输血策略.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 输血医学 输血医学
背景情况:
- 细胞还原性手术 (CRS) 与高热性腹膜内化学疗法 (HIPEC) 是腹膜转移的标准治疗方法.
- 在CRS/HIPEC期间显著的血液损失往往需要手术内红细胞 (RBC) 输血.
- 在CRS/HIPEC中,手术内包装红细胞输血 (iPRBT) 量对瘤结局的影响尚不清楚.
研究的目的:
- 为了研究手术内包装红细胞输血量与接受CRS/HIPEC治疗的患者的瘤结果之间的关联.
- 评估输血量对术后并发症和整体存活率 (OS) 的影响.
主要方法:
- 一项对128名接受CRS/HIPEC和手术内红细胞输血的患者进行的回顾性研究.
- 患者被分为低 (≤4单位) 和高 (>4单位) 输血组.
- 倾向分数匹配 (PSM) 用于控制混变量;48名患者在PSM后被分析.
主要成果:
- 高的iPRBT体积与更高的CC得分,更大的血液损失,更长的手术时间,高的术前腹膜癌指数 (PCI) 和较低的术前血小板计数有关.
- 低输血组和高输血组之间没有观察到术后并发症率的显著差异 (P=.768).
- 与低输血量 (74.8%,62.8%;P=.019) 相比,高的iPRBT体积显着与1年和3年整体存活率 (OS) 的降低 (42.7%,18.3%) 相关.
结论:
- 在CRS/HIPEC中,较高的iPRBT体积可能为术后贫血提供暂时的好处,但与较低的长期存活率有关.
- 这些发现表明,对于接受CRS/HIPEC的患者,应该考虑采取更为严格的输血策略.
- 需要进一步的研究来阐明iPRBT与生存结果之间的关联背后的机制.
相关概念视频
Blood Transfusion
2.3K
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
2.3K
Blood Transfusion and Agglutination
14.7K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
14.7K
Sign Test for Matched Pairs
401
The sign test for matched pairs offers a robust method for comparing two paired samples, often for the effects of an intervention in one of them. This method is very useful in situations where the underlying distribution of the data is unknown. The test compares two related samples—often pre- and post-treatment measurements on the same subjects—to determine if there are significant differences in their median values.
To conduct the sign test, we first calculate the differences in...
To conduct the sign test, we first calculate the differences in...
401
Impact of Groups on Groups
241
Social psychologists analyze how groups influence one another, shaping social structures and interactions through both cooperation and competition. These dynamics manifest in various ways, ranging from economic partnerships to intergroup conflicts that shape societal structures and perceptions.Cooperation and Competition in Intergroup RelationsIntergroup relationships vary across contexts, sometimes fostering cooperation and mutual benefit while at other times leading to conflict and...
241
Blood Studies I: ABG and VBG
1.3K
Blood studies are critical in the medical field, enabling healthcare professionals to assess a patient's health status accurately. This page will focus on two significant blood studies: Arterial Blood Gas (ABG) and Venous Blood Gas (VBG).
Arterial Blood Gas (ABG)
Arterial Blood Gas (ABG) studies are crucial for assessing the lungs' ability to supply oxygen and remove carbon dioxide, reflecting the patient's ventilation status. They also help understand the kidneys' capacity to...
Arterial Blood Gas (ABG)
Arterial Blood Gas (ABG) studies are crucial for assessing the lungs' ability to supply oxygen and remove carbon dioxide, reflecting the patient's ventilation status. They also help understand the kidneys' capacity to...
1.3K
Red Algae
902
Red algae, also known as rhodophytes, are primarily found in marine environments, though some species inhabit freshwater and terrestrial ecosystems. These organisms exist in both unicellular and multicellular forms, with some multicellular varieties reaching macroscopic sizes.As phototrophic organisms, red algae contain chlorophyll a; however, their chloroplasts lack chlorophyll b. Instead, they possess phycobiliproteins, which serve as major light-harvesting pigments, similar to those found in...
902


