补充メラトニン可以降低重症患者的妄想发作率:系统性审查和元分析
Xiaoyu Wu1, Panxin Hu1, Haopeng Wu1
1Department of Emergency Medicine, The First People's Hospital of Taizhou, Taizhou, China.
Frontiers in pharmacology
|January 28, 2026
概括
黑色素有效地降低了危急病患者妄的发生率. 然而,它并没有显著影响妄的持续时间,重症监护室 (ICU) 停留,或死亡率.
科学领域:
- 关键护理医学 关键护理医学
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 痴呆症是重症患者的严重并发症,与更长的住院时间,增加的死亡率和认知缺陷有关.
- 扰乱的昼夜节律有助于妄想的发病,这表明黑激素是潜在的治疗剂.
- 现有证据表明,黑激素在预防重症监护室 (ICU) Delirium 的有效性是不一致的.
研究的目的:
- 系统地评估黑激素及其激动剂对成年ICU患者痴呆发病率和持续时间的影响.
- 评估对ICU停留时间和整体死亡率的影响.
- 为随机对照试验 (RCT) 提供全面的元分析.
主要方法:
- 系统性审查和RCT的元分析.
- 搜索的主要数据库 (PubMed,Embase,Scopus,Cochrane CENTRAL) 截至 2025 年 10 月.
- 包括在成人ICU患者中将黑色素/拉梅尔丁与安慰剂/标准护理进行比较的RCT.
主要成果:
- 分析了22个涉及3706名患者的RCT.
- 黑素显著降低了妄想发作的发生率 (RR 0.75,P=0.001).
- 没有发现对妄持续时间,ICU停留时间或死亡率有重大影响.
结论:
- 补充黑素有效降低了严重病情的成年人 Delirium 的发生率.
- 黑素似乎没有缩短妄的持续时间,减少ICU停留时间,或改善生存率.
- 研究结果支持黑激素用于妄的预防,其益处主要在于减少发生.
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