体重指数和早期结直肠癌风险:系统性审查和基于队列的元分析
Huichao Wang1, Chuanliang Wu1, Sheng Zhou1
1Spleen and Stomach Department (Gastroenterology Department), Fengxian District Hospital of Traditional Chinese Medicine, Shanghai, Shanghai, China.
Scandinavian journal of gastroenterology
|January 28, 2026
概括
体重指数 (BMI) 升高与早期结直肠癌 (EOCRC) 风险增加有关,特别是在肥胖个体和男性中. 体重管理对于预防年轻人群中的EOCRC至关重要.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 早期结直肠癌 (EOCRC) 的发病率在全球范围内正在上升.
- 高体重指数 (BMI) 是已知的结直肠癌风险因素,但其在EOCRC中的特定作用需要进一步澄清.
- 了解BMI和EOCRC之间的关联对于制定有针对性的预防策略至关重要.
研究的目的:
- 对队列研究进行更新的系统审查和元分析.
- 澄清BMI与早期结直肠癌风险之间的关联.
- 通过性别,地区和年龄来调查潜在的风险变化.
主要方法:
- 在主要数据库 (PubMed,EMBASE,Scopus等) 的系统文献搜索. 通过2025年8月.
- 包括11项报告诊断前BMI和EOCRC结果的队列研究.
- 使用随机效应模型进行元分析,以组合几率比率 (OR) 和95%置信区间 (CI).
主要成果:
- 超重/肥胖 (BMI ≥25 kg/m2) 与59%的EOCRC风险增加显著相关 (OR = 1.59).
- 与超重 (OR = 1.24) 相比,肥胖显示出更强的关联 (OR = 1.81).
- 与女性相比,男性 (OR = 1.50) 的风险较高 (OR = 1.16),但区域差异较大.
结论:
- 体重指数升高,特别是肥胖,与早期结直肠癌的风险增加有关.
- 肥胖症成为EOCRC的一个显著可修改的风险因素.
- 体重管理策略对于减轻年轻人EOCRC日益增加的全球负担至关重要.
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