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Updated: Jan 29, 2026

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DNTTIP1通过MIDAC介导的BMF的表观遗传沉默驱动白血病发生

Ruolin Xiu1,2, Yuzhu Ma1, Yueying Gao3

  • 1Department of Critical Care Medicine, Department of Hematology, NHC Key Laboratory of Cell Transplantation, Key Laboratory of Hepatosplenic Surgery of Ministry of Education, The First Affiliated Hospital of Harbin Medical University, Harbin, China.

Clinical and translational medicine
|January 28, 2026
PubMed
概括

脱氧核酸转移酶终端相互作用蛋白1 (DNTTIP1) 是急性白血病的关键表观遗传调节剂,通过静止BCL2-修饰因子 (BMF) 来控制白血病细胞存活率. 针对DNTTIP1-HDAC1/2-BMF轴提供了一个有前途的治疗策略.

关键词:
在 BMF BMF BMF 中.DNTTIP1 的意思是在 MiDAC 系统中,我们可以使用 MiDAC严重的急性白血病.灭症 (apoptosis) 是一种死亡的过程.自自是自的过程.

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