相当性和节约资源:整体血液与创伤复苏的成分疗法对比
Jacob W Roden-Foreman1, Michael E Johnston2, Nicole Lunardi2
1Trauma Administration, Texas Health Presbyterian Hospital Dallas, Dallas, Texas, USA.
Transfusion
|January 28, 2026
概括
在创伤护理中,低位数O+全血 (LTOWB) 与组件治疗相比,显示出类似的患者结果. 使用LTOWB减少了大量输血量和在复苏期间延长了生存时间.
科学领域:
- 创伤护理 创伤护理
- 输血医学 输血医学
- 紧急医疗 紧急医疗
背景情况:
- 民用创伤护理越来越多地使用低位数O+全血 (LTOWB).
- 一个基于设施的LTOWB计划于2020年11月启动.
- 对患者和资源结果的评估是由该计划的启动促成的.
研究的目的:
- 评估一个LTOWB程序的以患者为中心和与资源相关的结果.
- 为了在创伤患者中比较LTOWB和传统组件疗法之间的结果.
主要方法:
- 追溯队列研究,比较组分疗法和LTOWB.
- 患者在创伤中心到达后4小时内接受治疗 (2018年11月至2022年11月).
- 1:1匹配和双强度估计用于结果建模,不包括女性患者.
主要成果:
- 在所有评估变量中,LTOWB表现出同等或优异的结果.
- 在LTOWB中,急诊室死亡率显著降低 (12.7%vs20.9%).
- LTOWB与总大量输血量减少40%以及非幸存者的生存时间延长有关.
结论:
- LTOWB计划的结果与组件疗法相似.
- 通过减少输血量,LTOWB使用可以节约血液产品.
- 在严重受伤的患者中,LTOWB提供了改善外科救援机会的潜力.
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