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Updated: Jan 29, 2026

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在临床前模型中,泡泡进化引导的相互连接的等级性宏海绵用于非可压缩的血静
Zheng Pan1, Ming Li2,3, Chong Zhang1
1Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Advanced materials (Deerfield Beach, Fla.)
|January 28, 2026
概括
一种新型的注射性静血海绵 (IHMS) 通过扩张和密封伤口,有效地阻止严重出血. 这种先进的材料在临床前模型中表现出卓越的性能,为创伤伤害提供了有前途的解决方案.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 创伤护理 创伤护理
背景情况:
- 失控的非压缩性出血带来了重大的治疗挑战.
- 现有的静血材料通常在孔隙性,机械强度和生物相容性方面存在局限性.
研究的目的:
- 开发一种可注射,自我扩张的静血海绵 (IHMS),具有增强的特性.
- 在临床前模型中评估IHMS的静血疗效和生物相容性.
主要方法:
- 使用真空辅助泡策略,创建一个具有互连毛孔的巨孔海绵.
- 采用双网矩阵来增强机械稳定性和耐疲劳性.
- 在各种出血模型中评估IHMS的性能,包括肝脏穿孔,大腿动脉切割和致命的猪出血.
主要成果:
- 优化的IHMS表现出了出色的机械强度,在重复压缩后保持了显著的应力和应变.
- 在吸收液体,保持血液,凝块形成和密封能力方面,IHMS的表现优于商业血静止剂.
- 临床前研究表明,即使在抗凝剂下,在老鼠和猪模型中,血静效率优越,并且在血静后容易去除.
结论:
- 开发的IHMS为危及生命的出血提供了高性能静血解决方案.
- 它的设计克服了当前材料的局限性,显示了在创伤管理中临床应用的潜力.
- IHMS表现出抗菌活性,生物相容性,并促进组织修复,推进可扩展血静止器技术.
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