与难以管理的轴性脊柱关节炎相关的临床和放射性因素:一个多中心研究
Haluk Cinakli1, Mete Kara2, Gülay Alp3
1Rheumatology Department, Kırklareli Training and Research Hospital, Kırklareli, Turkey.
International journal of rheumatic diseases
|January 28, 2026
概括
该研究在11.2%的患者中发现了难以管理的轴性脊椎关节炎 (axSpA),其特征是较高的疾病活性和特定的并发症. 优化治疗策略对于这些患者至关重要.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 临床医学 临床医学
背景情况:
- 轴性脊柱关节炎 (axSpA) 造成了严重的疾病负担.
- 国际脊椎关节炎评估协会 (ASAS) 最近定义了难以管理的axSpA (D2M-axSpA).
- 了解D2M-axSpA的特性对于有效管理至关重要.
研究的目的:
- 用ASAS对D2M-axSpA.的定义来评估axSpA的临床特征,疾病负担和治疗模式.
- 为了确定与D2M-axSpA.相关的因素.
主要方法:
- 一项多中心横截面研究招募了383名axSpA患者.
- 根据之前的b/tsDMARD使用和持续的疾病活性,患者被归类为D2M-axSpA.
- 后勤回归分析确定了与D2M-axSpA.A.相关的因素.
主要成果:
- 11.2%的患者符合D2M-axSpA的标准.
- D2M-axSpA患者表现出较高的炎症标志物,疾病活性和功能障碍.
- 之前的脑膜炎,外周关节炎,并发症和吸烟史与D2M-axSpA相关.
结论:
- D2M-axSpA具有相当大的临床和放射性负担.
- 对于D2M-axSpA患者,需要优化治疗策略.
- 应特别注意患有并发症,前膜炎,外周关节炎或吸烟史的患者.
相关概念视频
Esophageal Perforation-II: Clinical Manifestations and Management
715
Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
Clinical Manifestations:
715
Barrett Esophagus-II: Clinical Manifestations and Management
1.0K
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
1.0K
Esophageal Varices-II: Clinical Features and Management
548
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
548
Gastritis III: Clinical Manifestations and Management
1.2K
The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
1.2K
Esophageal Strictures-II: Clinical Features and Management
605
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
605
Acute Pancreatitis II: Clinical Manifestations and Management
840
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
840


