标本性肥胖与2型糖尿病死亡率的年龄分层关联
Shinta Yamamoto1, Yoshitaka Hashimoto1,2, Fuyuko Takahashi1
1Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
形肥胖症显著增加了日本2型糖尿病患者的死亡风险,特别是40-75岁的患者. 仅仅是肉症,而不是肉性肥胖症,对75岁以上的人来说,风险更高.
科学领域:
- 老年学是一门学科.
- 代谢疾病 代谢疾病
- 流行病学 流行病学
背景情况:
- 由肌肉损失和多余脂肪为特征的sarcopenic肥胖症与健康状况不佳有关.
- 有限的证据表明,sarcopenic肥胖对2型糖尿病患者的死亡率的影响有限.
研究的目的:
- 为了研究 sarcopenic 肥胖和日本2型糖尿病患者的死亡风险之间的关联.
- 探索与sarcopenic肥胖及其组成部分相关的特定年龄的死亡风险.
主要方法:
- 形肥胖症的定义是使用日本形肥胖症工作组的标准.
- 考克斯比例危险模型用于评估死亡风险.
- 根据年龄组 (40-75岁与>75岁) 进行的子组分析.
主要成果:
- 相比于没有sarcopenia或肥胖症,sarcopenic肥胖症与2.89倍的死亡风险增加有关 (p=0.048).
- 在40至75岁的人群中,在sarcopenic肥胖症中,死亡风险显著增加 (aHR 13.1,p<0.001).
- 在75岁以上的个体中,单独的肉症,而不是肉性肥胖症,与较高的死亡率有关.
结论:
- 肥胖症是日本2型糖尿病患者死亡率增加的重要预测因素.
- 与sarcopenic肥胖相关的死亡风险在40-75岁年龄组中特别高.
- 单独的皮症,而不是皮性肥胖症,是75岁以上2型糖尿病患者的关键死亡风险因素.
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