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Updated: Jan 29, 2026

Isolation of Soluble and Insoluble PrP Oligomers in the Normal Human Brain
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Isolation of Soluble and Insoluble PrP Oligomers in the Normal Human Brain

Published on: October 3, 2012

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人类突触对可溶性陶寡合物的选择性脆弱性

Shrinath Kadamangudi1, Laura Sanchez-Sanchez1, Rakez Kayed1

  • 1Mitchell Center for Neurodegenerative Diseases, Department of Neurology, University of Texas Medical Branch, Galveston, TX, USA.

Journal of Alzheimer's disease : JAD
|January 28, 2026
PubMed
概括

有毒的寡聚物 (tauO) 主要对人类大脑中的前突触GABAergic突触造成伤害. 这种抑制神经传递的脆弱性可能会导致早期病功能障碍和传播.

关键词:
阿尔茨海默病的疾病阿尔茨海默病的疾病.主要与年龄相关的病症 (PART)突触的脆弱性突触的脆弱性的寡合体是tau的寡合体.

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