针对与青少年突然心脏病死亡有关的疾病的基于人口的查:系统性审查和元分析
Francesca Bonanni1, Angelo Capodici1, Francesco Gentile1,2
1Health Science Interdisciplinary Centre, Scuola Superiore Sant'Anna, Pisa, Italy.
European heart journal. Quality of care & clinical outcomes
|January 28, 2026
概括
系统的心血管查可以识别患心脏突然死亡 (SCD) 风险的青少年. 然而,需要对长期结果和成本效益进行更多的研究,以告知公共卫生政策.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 儿科 儿科 儿科
背景情况:
- 青少年突然心脏死亡 (SCD) 主要是由遗传性或先天性心脏病引起的.
- 虽然对竞技运动员的查已经建立,但对一般年轻人群体的群体查缺乏证据.
- 目前的指导方针强调需要评估针对年轻人的大规模查计划的价值.
研究的目的:
- 系统地审查大规模心血管查计划在年轻人中检测SCD风险状况的有效性.
- 评估通过大规模查发现的SCD风险状况的诊断产量和患病率.
- 识别有关此类计划的长期成果和成本效益的证据缺口.
主要方法:
- 按照PRISMA指南进行了系统审查,该协议在PROSPERO.中注册.
- 包括评估年轻人心血管查的原始研究 (不包括专项运动员研究).
- 分析了19项使用心电图 (ECG) 和/或问卷的研究 (1,079,781名参与者).
主要成果:
- 对SCD风险状况的整体诊断收益率为1.4‰ (在元分析中为1.9‰).
- SCD风险状况的综合流行率为2.23‰ (95% CI:0.94 - 5.29‰),具有很高的异质性 (I2 = 100%).
- 大多数研究针对6-19岁的年龄段,其中结合心电图和问卷的查最常见 (68.4%).
结论:
- 系统的心血管查显示,有可能识别有风险的年轻人,具有有意义的诊断产量.
- 由于缺乏长期结果和成本效益数据,需要进一步研究.
- 完善查协议和评估可持续性对于基于证据的公共卫生政策至关重要.
相关概念视频
Review and Preview
8.4K
In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
Percentiles are a type of fractile that partition data into...
8.4K
Review and Preview
11.2K
Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.2K
Analysis of Population Pharmacokinetic Data
733
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
733
Conservation of Small Populations
17.1K
Small population sizes put a species at extreme risk of extinction due to a lack of variation, and a consequent decrease in adaptability. This weakens the chances of survival under pressures such as climate change, competition from other species, or new diseases. Large populations are more likely to survive pressures such as these, as such populations are more likely to harbor individuals that have genetic variants that are adaptive under new stresses. Small populations are much less...
17.1K
What is Population Genetics?
64.7K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
64.7K
Population Growth
28.4K
Population size is dynamic, increasing with birth rates and immigration, and decreasing with death rates and emigration. In ideal conditions with unlimited resources, populations can increase exponentially, which plots as a J-shaped growth rate curve of population size against time. This type of curve is characteristic of newly-introduced invasive species, or populations that have suffered catastrophic declines and are rebounding.
28.4K


