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Updated: Jan 29, 2026

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丹麦国家对ocrelizumab与natalizumab在多发性硬化症中的有效性研究
Camilla Maersk-Moller1,2, Luigi Pontieri3, Morten Leif Munding Stilund4,5
1Department of Neurology, Multiple Sclerosis Clinic, Aarhus University Hospital, Aarhus N, Denmark.
European journal of neurology
|January 28, 2026
概括
这项研究发现ocrelizumab和natalizumab治疗复发性复发性多发性硬化症 (RRMS) 的有效性没有显著差异. 这两种药物在复发率,残疾进展和MRI活性方面表现相似.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 药理学 药理学 是一个学科.
背景情况:
- 奥克雷利祖马布和纳塔利祖马布已被确立为复发性复发性多发性硬化症 (RRMS) 的疾病修饰治疗方法.
- 比较有效性研究对于在RRMS管理中做出明智的临床决策和患者护理至关重要.
研究的目的:
- 为了比较ocrelizumab与natalizumab在控制RRMS患者的疾病活动和进展方面的有效性.
- 为了评估两种治疗方法之间的年度复发率 (ARR),不依赖复发活动的进展 (PIRA) 和MRI病变活动的差异.
主要方法:
- 一个全国性的,多中心的,使用丹麦全国性多发性硬化病登记册 (2018年1月 - 2023年4月) 的比较有效性研究.
- 包括接受了ocrelizumab或natalizumab治疗的RRMS患者.
- 应用治疗权重的逆概率 (IPTW) 来调整混因素.
主要成果:
- 在ocrelizumab和natalizumab组之间的年复发率 (ARR) 中没有观察到统计学上显著的差异.
- 治疗组之间独立于复发活动 (PIRA) 的时间到第一个进展并没有显著差异.
- 在接受ocrelizumab和natalizumab治疗的患者之间,在MRI扫描上发现新的或扩大的T2/增强对比度的病变发生率没有显著差异.
结论:
- 这项全国性的注册研究没有证明ocrelizumab和natalizumab的有效性有所不同.
- 这两种治疗方法在RRMS患者的复发风险,残疾进展和MRI检测到的疾病活性方面显示了相似的结果.
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