在混合IVUS-OCT图像中基于深度学习的斑块表征优于单模深度学习分析和人类专家的单模深度学习分析:与组织学的头对头比较
Retesh Bajaj1,2,3, Xingru Huang4, Natasha Alves-Kotzev5
1Department of Cardiology, St Michael's Hospital, Toronto, Canada.
Cardiovascular research
|January 28, 2026
概括
在组织学数据上训练的新型深度学习 (DL) 分类器改善了混合血管内超声波光学连贯断层扫描 (IVUS-OCT) 图像中的斑块特征. 这种先进的DL模型在分类斑块组件和表型方面优于单模式DL分类器和专家分析师.
科学领域:
- 心血管成像 - 心血管成像
- 人工智能在医学中的应用
- 组织病理学 组织病理学
背景情况:
- 混合血管内超声波-光学连贯性断层扫描 (IVUS-OCT) 与单一模式相比,提供了增强的斑块表征.
- 解释IVUS-OCT图像以进行精确的斑块分析是复杂且耗时的.
- 深度学习 (DL) 为自动化和改进图像解释提供了一个潜在的解决方案.
研究的目的:
- 开发和评估一种新的组织学训练深度学习 (DL) 分类器,用于混合IVUS-OCT图像中的斑块成分分类.
- 为了比较混合IVUS-OCTDL分类器与单模式DL分类器 (IVUS-DL,OCT-DL) 和专家分析师的性能.
主要方法:
- 使用了10个尸体的人类心脏与匹配的IVUS-OCT图像和组织学剖析.
- 在992个上训练了三个DL分类器 (IVUS,OCT,IVUS-OCT),并在264个上进行了测试,组织学数据定义了地面真相.
- 将DL分类器性能和专家注释与斑块表型和组织类型分类的组织学进行比较.
主要成果:
- 与IVUS-DL (0.19),OCT-DL (0.35) 和专家 (0.53) 相比,混合IVUS-OCT DL分类器在检测斑块表型 (Kappa 0.60) 中表现出优异的性能.
- 混合DL分类器准确地分类了68%的组织学定义的纤维肌瘤.
- 在评估组织类型方面获得了86.7%的整体准确性,超过IVUS-DL (73.2%),OCT-DL (66.6%) 和专家 (70.6%).
结论:
- 经过组织学训练的混合IVUS-OCT DL分类器可用于斑块表征.
- 这种方法可以更准确地检测斑块成分和表型分类.
- 混合DL分类器在准确性方面超过单模式DL分类器和专家分析师.
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