慢性肝病患者中肝炎E病毒感染:拉丁美洲多中心研究
Anabella Clara Fantilli1,2, María Belén Pisano1,2, Maribel Martínez Wassaf3
1Facultad de Ciencias Médicas, Instituto de Virología "Dr. J.M. Vanella", Universidad Nacional de Córdoba, Córdoba, Argentina.
The Journal of infectious diseases
|January 28, 2026
概括
肝炎E病毒 (HEV) 感染在拉丁美洲慢性肝病患者中很常见,因国家而异. 建议对肝硬化或与酒精有关的肝病患者进行测试,这些患者有无法解释的肝脏问题.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 流行病学 流行病学
背景情况:
- 肝炎E病毒 (HEV) 是全球急性肝炎的重要原因之一.
- 慢性肝病患者面临HEV相关并发症的风险增加.
- 在HEV易感性中PROGINS哈普洛型的作用需要研究.
研究的目的:
- 为了评估拉丁美洲的CLD患者中HEV感染的流行率.
- 为了确定与HEV感染相关的因素,包括PROGINS亚型.
- 要了解这个研究不足的地区的HEV流行病学.
主要方法:
- 分析了6个拉丁美洲国家的971名个人 (784名CLD患者,187名健康对照).
- 使用血清学和分子技术检测抗HEVIgG/IgM,HEV-RNA和PROGINS杂型.
- 植物遗传学分析用于HEV基因型和菌株鉴定.
主要成果:
- 总体抗HEVIgG血清流行率为15.2%,在CLD患者和对照人群之间没有显著差异.
- 血清患病率存在显著的地理差异,特别是在智利高 (45.1%),在阿根廷低 (4.2%).
- 肝硬化和与酒精有关的肝病 (ALD) 与更高的HEV检测率有关; PROGINS单元型没有显示任何关联.
结论:
- 在拉丁美洲的HEV血清流行在不同国家是异质的.
- 应考虑对慢性结核病患者进行HEV检测,特别是那些患有肝硬化或ALD,呈现出无法解释的肝脏问题的人.
- 动物性HEV-3菌株正在该地区流传,这得到了植物遗传学分析的证实.
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