对化学品和材料整体影响评估的预测模型和整合策略的审查
Angela Serra1,2, Marcella Torres Maia1, Periklis Tsiros3
1Finnish Hub for Development and Validation of Integrated Approaches (FHAIVE), Faculty of Medicine and Health Technology, Tampere University, 33100 Tampere, Finland.
Environmental science & technology
|January 28, 2026
概括
整合预测模型可以增强化学品安全评估. 这种方法提供了对化学物质影响的整体观点,优化功能,成本,安全和可持续性,以实现更好的材料创新.
科学领域:
- 化学品安全和可持续性评估的评估.
- 材料科学与创新 材料科学与创新
- 预测建模和数据科学数据科学
背景情况:
- 快速的化学和材料创新需要综合影响评估框架.
- 安全和可持续设计 (SSbD) 框架评估生命周期安全和可持续性.
- 当前的SSbD方法往往独立地应用模型,限制了整体理解.
研究的目的:
- 审查现有的化学和材料影响评估预测模型.
- 描述整合这些模型进行综合评估的策略.
- 在综合框架内解决模型不确定性和适用性领域.
主要方法:
- 研究了三个模型集成策略:共识集成,加权聚合和管道集成.
- 分析了适用于人类健康,环境和社会经济因素的现有预测模型.
- 在综合建模中研究了不确定性和适用性领域的概念.
主要成果:
- 确定共识,加权聚合和管道集成作为组合模型预测的关键策略.
- 强调解决模型不确定性和定义综合框架适用领域的重要性.
- 展示了综合模型如何促进对化学和材料影响的更连贯和更准确的评估.
结论:
- 综合建模方法提供了更全面,更准确的化学和材料安全和可持续性的评估.
- 解决模型不确定性和适用性领域对于有效的综合框架至关重要.
- 这些策略支持在化学创新的同时优化功能,成本,安全和可持续性.
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