在免疫能力较强的主体中传播性菌菌:增加识别和及时诊断的机会
Anna C H Hoge1, Thomas E Grys1, Erin H Graf1
1Department of Laboratory Medicine and Pathology, Mayo Clinic, Phoenix, AZ, United States.
Clinical chemistry
|January 28, 2026
概括
在免疫能力强的宿主中传播的菌菌症经常面临诊断延迟,即使有阳性抗体测试. 提高对风险因素和症状的认识对于及时诊断和治疗至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 菌类学 菌类学是指菌类学.
- 免疫受损宿主研究
背景情况:
- 虫虫种类 (Coccidioides spp.) 是一种虫. 感染可以导致严重的,扩散的疾病,特别是在风险人群中.
- 由于测试的限制和不充分考虑,诊断往往会延迟,特别是在免疫能力较强的个体中.
- 肺外菌带有高发病率和死亡率,如果没有及时的抗真菌治疗.
研究的目的:
- 在免疫能力较强的患者中鉴定散发性菌菌病例的特征.
- 识别诊断延迟及其促成因素.
- 评估一次性查测试对扩散型菌菌菌的有用性.
主要方法:
- 在7年内对40名患有扩散性菌菌病的免疫能力强的患者进行了回顾性分析.
- 检查诊断时间表和初始呈现设置.
- 对Coccidioides spp.的评估 免疫球蛋白G (IgG) 酶免疫试验结果.
主要成果:
- 所有40例 (100%) 的病例均呈阳性Coccidioides spp. 通过FDA批准的免疫试验获得IgG抗体.
- 观察到诊断的显著延迟 (87%),与疾病恶化 (71%) 相关联.
- 延迟诊断发生在初级保健 (56%),急诊室 (33%) 和流行地区的紧急护理 (11%).
结论:
- 在免疫能力强的宿主中,传播性菌菌病的诊断经常被推迟.
- 阳性 Coccidioides spp. 这种病原体. 在分散的病例中,IgG抗体始终存在.
- 提高临床医生对风险因素,症状和诊断测试的认识至关重要.
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