激素替代疗法是否会影响梅拉斯马的发展? 对证据和管理指南的审查
Sabriya Abdeen1, Emily Shao2, Davin Lim3,4
1Royal Brisbane and Women's Hospital, Brisbane, Australia.
概括
荷尔蒙替代疗法 (HRT) 对质瘤的研究不足. 高剂量口服仅用雌激素的HRT显示了最强的关联,需要为处于危险的个体提供咨询和光保护.
科学领域:
- 皮肤病学 皮肤病学
- 内分泌学 在内分泌学.
背景情况:
- 黑色素是一种常见的超色素障碍,受到紫外线暴露,遗传学和荷尔蒙的影响.
- 虽然已知与怀孕和口服避孕药的相关性,但激素替代疗法 (HRT) 的影响尚未得到充分研究.
研究的目的:
- 评估链接HRT和黑色素瘤的证据.
- 提出基于证据的管理指南,对HRT相关的黑色素瘤.
主要方法:
- 在PubMed,Embase和Scopus进行了文献搜索.
- 包括对各种HRT配方的研究:口服仅用雌激素,组合HRT,透皮,局部和阴道雌激素.
- 根据证据的强度制定指导方针.
主要成果:
- 有限的证据,主要是病例报告.
- 高剂量口服仅用雌激素的HRT具有最强的记录相关性,特别是在菲茨帕特里克类型III-VI的前臂肌瘤中.
- 有口服和透皮HRT的病例报告;局部和阴道HRT的证据很少. 在体外受精没有显示任何关联.
结论:
- 在文献中,HRT相关的乳腺瘤的代表性不足.
- 临床医生应为有风险的妇女提供有关乳腺瘤的咨询,并强调光保护.
- 需要进行前性研究来澄清不同HRT配方的风险.
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