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在内蒙古少数民族家庭中共享的微生物群的类型和特征

Caiqing Yao^1,2, Lijun You^1,3, Jing Li¹

¹Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot, China.

Microbiology spectrum

|January 28, 2026

概括

家庭同居显著塑造肠道微生物多样性,影响社区组成和物种内的遗传变异. 在内蒙古少数民族家庭中发现了共享的细菌菌株,通常具有短链脂肪酸生产的基因.

科学领域:

微生物学微生物学
人类肠道微生物群
基因组学就是基因组学.

背景情况:

人体肠道微生物群的组成在个体之间有很大差异.
微生物物种内的遗传异质性比社区组成的理解要少.
内蒙古的少数民族有独特的饮食模式,可能会影响肠道健康.

研究的目的:

描述内蒙古少数民族家庭的肠道微生物组成和遗传多样性.
识别家族内共享的细菌菌株,并评估它们的功能潜力.
了解影响肠道微生物群在宏观和微观层面变化的因素.

主要方法:

研究了来自内蒙古的25个少数民族家庭的肠道微生物组成.
利用平均核酸标识来识别共享的细菌菌株.
对基因和基因组的京都百科全书 (KEGG) 数据库进行注释的共享菌株.
分析了基因多态度比率 (pN/pS) 和微生物相互作用网络.

主要成果:

家庭中的同居是肠道微生物多样性变化的主要决定因素.
确定了17种在家族内共享的细菌菌株,其中Bifidobacterium adolescentis和Holdemanella biformis的丰度更高.
大多数共享菌株拥有短链脂肪酸 (SCFA) 生产基因,并表现出较低的PN/PS比率.
除了Clostridiales细菌之外,共享的菌株通常在微生物相互作用网络中占据了边缘位置.

结论:

家庭共同生活在两种多样性层面上都在塑造肠道微生物群中发挥着至关重要的作用.
在家族内共享的肠道细菌具有功能潜力,特别是在SCFA生物合成中.
这些发现为为少数民族群体开发特定家庭的益生菌干预提供了基础.

关键词:

家庭家庭家庭家庭肠道微生物多样性肠道微生物多样性我们的肠道微生物群.分享的微生物群.

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