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素酸通过调节肠道微生物群来改善小鼠DSS诱导的大肠炎

Qinqiu Zhang¹, Shixiong Deng¹, Yiya Sun¹

¹Sichuan Key Laboratory of Fruit and Vegetable Postharvest Physiology, College of Food Science, Sichuan Agricultural University, Ya'an, Sichuan 625014, China. qinwen@sicau.edu.cn.

Food & function

|January 28, 2026

概括

酸 (CGA) 通过改善肠道微生物群平衡,有效地减少了小鼠的大肠炎的严重程度. 这种多促进有益细菌和恢复短链脂肪酸,证明了其抗炎功能.

科学领域:

胃肠病学胃肠病学
微生物学微生物学
药理学药理学是指药理学的学科.

背景情况:

酸 (CGA) 是一种具有已知的抗炎性质的植物多.
通过CGA调节肠道微生物群以缓解大肠炎的确切机制仍然不完全理解.

研究的目的:

在小鼠模型中研究CGA的抗炎作用,研究由酸 (DSS) 诱导的大肠炎的小鼠模型.
阐明CGA对肠道微生物群组成和结肠炎期间短链脂肪酸 (SCFA) 生产的影响.

主要方法:

给小鼠服用DSS来诱导大肠炎,随后补充CGA.
评估了疾病活动指数 (DAI) 和结肠组织学损伤.
用测序技术分析了肠道微生物群的组成.
量化了SCFA含量,包括酸和黄油酸.

主要成果:

补充CGA显著减轻大肠炎的严重程度,减少DAI和修复组织损伤.
CGA缓解了DSS诱导的肠道微生物群失调,降低了F/B比率.
CGA促进了诸如Akkermansia muciniphila,Odoribacter和Muribaculaceae等有益细菌的生长.
补充CGA可以逆转SCFA发生的变化,特别是增加酸和黄油酸.

结论:

在DSS诱导的大肠炎中,CGA显示出显著的抗炎作用.
通过恢复肠道微生物群平衡和促进有益细菌,CGA可以改善肠道炎症.
这些发现强调了CGA在通过肠道微生物群调节和SCFA生产来治疗大肠炎的潜在治疗作用.

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