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Updated: Jan 29, 2026

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
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Published on: December 29, 2021

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对于高效和可控的RNA寡核酸合成,聚聚酶的计算演化

Lixiang Yang1, Yi He2, Fuyan Cao2

  • 1MGI Tech, Shenzhen 518083, China.

Nucleic acids research
|January 28, 2026
PubMed
概括

我们使用人工智能和机器学习设计了多聚合酶 (PUP) 变体,以改进RNA合成. 新的PUPdel2酶显示了对修饰核酸的增强稳定性和催化效率.

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