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一个TFAP4-UBC9-SUMO1轴在糖尿病并发症中调节病态线粒体过裂

Zhiyu Jin1, Ying Jiang1,2, Dayun Tao2

  • 1Department of Cardiology, School of Medicine, South China University of Technology, Guangzhou, 510006, China.

Acta diabetologica
|January 28, 2026
PubMed
概括

TFAP4-UBC9-SUMO1轴通过促进过度裂变和线粒细胞衰变,驱动糖尿病中线粒体损伤. 这一途径为糖尿病器官并发症提供了一个新的治疗点.

关键词:
DRP1 DRP1 的使用方法糖尿病并发症 糖尿病并发症线粒体功能障碍 线粒体功能障碍线粒体裂变的线粒体裂变线粒细胞衰变 - - 线粒细胞衰变 (mitophagy) 是一种这就是SUMOylation的作用.转录组分析 转录组分析

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