循环sPD-L1作为瘤微环境衍生的生物标志物:提高乳腺癌诊断区分的准确性
Yue Zhang1, Shuyi Chen2, Jie Ma3
1Clinical Medical Laboratory Center, Gaogang Branch, Taizhou School of Clinical Medicine, Nanjing Medical University, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, 225300, China. yue_zhang@aa.seu.edu.cn.
Cancer immunology, immunotherapy : CII
|January 28, 2026
概括
乳腺癌患者血清中的可溶性编程细胞死亡配体1 (sPD-L1) 含量升高,为诊断和瘤微环境评估提供一种非侵入性生物标志物. 这种生物标志物显示出超越传统标志物的诊断潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 生物化学 生物化学
背景情况:
- 编程细胞死亡连接体1 (PD-L1) 对于乳腺癌的免疫规避至关重要.
- 基于组织的PD-L1检测是侵入性和空间异质的.
- 可溶性PD-L1 (sPD-L1) 提供了一个潜在的非侵入性替代品.
研究的目的:
- 研究循环sPD-L1作为乳腺癌诊断的非侵入性生物标志物.
- 评估sPD-L1与瘤微环境 (TME) 和炎症标志物的相关性.
- 将sPD-L1的诊断性能与传统生物标志物进行比较.
主要方法:
- 在健康人群和乳腺癌患者中测量了血清sPD-L1水平.
- 分析了与炎症标志物和临床病理学数据的相关性.
- 接收器操作特征 (ROC) 曲线分析与诊断性能进行比较.
- 在体外共同培养实验中评估了细胞相互作用和细胞因子分泌.
主要成果:
- 与对照组相比,乳腺癌患者的循环sPD-L1显著升高.
- 较高的sPD-L1水平与晚期和转移相关.
- 通过ROC分析,sPD-L1表现出比CEA和CA15-3更好的诊断歧视.
- 在体外研究表明,sPD-L1和IL-6的同时诱导.
结论:
- 循环sPD-L1是一种有前途的乳腺癌非侵入性生物标志物.
- sPD-L1反映了TME状态和疾病进展.
- sPD-L1具有用于乳腺癌诊断歧视的潜力.
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