在主导半球拉斯穆森脑炎中响应神经刺激的长期结果
Hira Zafar1, Salman Zahoor1, Sarah Cobb2
1Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Acta neurologica Belgica
|January 28, 2026
概括
响应性神经刺激 (RNS) 有效地减少了拉斯穆森脑炎 (RE) 患者的发作和稳定功能,患者患有持续性折射性 (EPC),为高风险手术提供了可行的替代方案.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 发病学 (Epileptology) 是一个专业的学科.
背景情况:
- 拉斯穆森脑炎 (RE) 是一种罕见的,免疫介导的疾病,导致渐进的脑功能障碍和难治性.
- 部分性持续性 (EPC) 是RE中特别残疾的发作类型.
- 半球失联提供了控制,但带来了显著的功能风险,特别是在主导半球参与.
研究的目的:
- 评估响应神经刺激 (RNS) 的疗效和安全性,在患有主导半球RE和耐火EPC的儿科患者中.
- 评估RNS作为高功能风险患者手术切断的替代方案.
主要方法:
- 一名13岁的男性患有耐药RE和EPC,接受了非标签的RNS植入.
- 内EEG和fMRI指导电极放置在左侧周区域.
- 启动了RNS治疗,并在30个月内监测结果,包括发作频率,功能状态和不良事件.
主要成果:
- RNS显著减少了50%以上的EPC负担,使长期发作从4000-6000/天减少到600/天.
- 在整个治疗期间,认知,语言和运动功能保持稳定.
- 没有观察到与设备或刺激相关的不良反应,即使与同时进行免疫抑制治疗.
结论:
- 响应性神经刺激在不适合半球断开连接的RE患者中提供了有意义的减和功能稳定.
- RNS是监测型活动和指导治疗的宝贵生物标志物.
- 包括RNS在内的神经调节代表了在RE中管理耐火EPC的有希望和不断发展的战略,特别是在主导半球病例中.
相关概念视频
Incomplete Dominance
30.0K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
30.0K
Cerebral Hemispheres
2.4K
The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...
2.4K
Long-term Depression
33.2K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.2K
Predicting Reaction Outcomes
10.8K
Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
10.8K
Outcomes of Glycolysis
107.1K
Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
107.1K
Guidelines for Writing Outcome
3.8K
When developing expected outcomes for a patient care plan, the nurse should adhere to the following recommendations:
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care...
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care...
3.8K


