在老年人中,辅酶Q10的补充会提高血水平,但不会改善线粒体功能
Malte Schmücker1, Cathrine Tranberg2, Jacob Borch2
1Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark. malte.schmucker@sund.ku.dk.
GeroScience
|January 28, 2026
概括
在健康的老年人中,辅酶Q10 (CoQ10) 补充剂增加了血水平,但没有改善线粒体功能或身体表现. 需要进一步的研究来确定CoQ10的含量.
科学领域:
- 老年学是一门学科.
- 线粒体生物学 线粒体生物学
- 营养科学 营养科学
背景情况:
- 线粒体功能障碍与衰老有关,并影响能量代谢和氧化应激.
- 辅酶Q10 (CoQ10) 对线粒体功能至关重要,并充当抗氧化剂.
- CoQ10生物合成和线粒体功能可能会随着年龄的增长而下降,这表明补充剂的潜在益处.
研究的目的:
- 调查12周辅助辅酶Q10 (CoQ10) 对老年人线粒体功能和相关健康标志物的影响.
- 为了评估线粒体呼吸能力,氧化应激和CoQ10水平的变化,以应对CoQ10摄入.
- 评估CoQ10对葡萄糖平衡,体力表现 (VO2max) 和身体组成的影响.
主要方法:
- 这是一项为期12周的双盲,随机,安慰剂对照试验,涉及40名健康的老年人 (74±4岁).
- 参与者每天接受口服CoQ10 (400毫克) 或安慰剂.
- 进行了肌肉活检,口服葡萄糖耐受性测试 (OGTT),VO2max测试,以及线粒体功能,CoQ10水平和身体成分的评估.
主要成果:
- 补充后,血中的CoQ10水平显著增加,但组织和线粒体的CoQ10水平保持不变.
- 在线粒体呼吸能力,H2O2排放或线粒体含量方面,没有观察到CoQ10和安慰剂组之间的显著差异.
- 葡萄糖平衡,VO2max,休息代谢率,认知功能和身体组成没有显著变化.
结论:
- 在老年人中,服用CoQ10补充剂12周有效地增加了CoQ10的血度.
- 在这个强壮的老年人群中,补充CoQ10并没有提高线粒体功能,葡萄糖代谢或身体表现.
- 这些发现表明,辅酶Q10补充可能不足以改善健康老龄化个体的线粒体健康或性能.
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