补腺炎患者报告的结果措施:系统性审查和元分析
Nawar Tarafdar1, Meghna Varambally1, Nima Karimi1
1Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
JAMA dermatology
|January 28, 2026
概括
这次审查评估了患者报告的治疗结果指标 (PROMs) 对于补性炎 (HS),发现7个PROMs适合临床使用. 建议进行进一步的研究,以加强对HS特定仪器的验证.
科学领域:
- 皮肤病学 皮肤病学
- 临床试验 临床试验
- 健康 结果 研究 研究 结果
背景情况:
- 补腺炎 (HS) 是一种具有显著心理社会影响的慢性炎症性皮肤疾病.
- 患者报告的结果测量 (PROM) 越来越多地用于HS试验,但其质量和验证有所不同.
- 需要对HS特异性PROM进行系统评估,以指导临床和研究应用.
研究的目的:
- 使用基于共识的健康测量仪器选择标准 (COSMIN) 框架,系统地审查状腺炎supurativa特定的PROM.
- 评估这些PROM的发展质量和心理测量证据.
- 为在HS研究和临床实践中使用PROM提供建议.
主要方法:
- 在MEDLINE,Embase和PubMed进行了系统的文献搜索,截至2025年10月23日.
- 包括对HS特异性PROM与心理测量属性评估的研究;通用仪器被排除在外.
- 数据提取,偏差风险评估 (COSMIN 检查清单) 和证据质量分级 (COSMIN 修改的 GRADE) 是由两名独立审查员进行的.
主要成果:
- 在26项涉及5811名患者的研究中,确定了15种独特的HS特异性PROM.
- 14个PROM实现了足够的内容有效性,8个达到仪器开发的高标准.
- 这17项Hidradenitis Suppurativa生活质量 (HiSQOL-17) PROM显示出强大的内部一致性和构造有效性. 七个PROM符合Cosmin的推标准.
结论:
- 七个特定于Hidradradenitis suppurativa的PROM显示出足够的内容有效性和关键测量特性.
- HiSQOL-17 PROM表现出强大的心理测量特性,用于评估HS患者的生活质量.
- 需要进行进一步的研究,以加强对综合患者评估的HS特定仪器的验证.
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