在哺乳动物前肢运动控制的基础上,髓和C3-C4脊柱直径
Vishwas Jindal1, Matteo M Grudny1, Daniel W Wesson2
1Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32608.
概括
一项新的研究揭示了在人类和小鼠中,前肢运动控制的保留的皮质骨髓网络. 这个网络涉及脑干和脊髓,为精细的手动控制提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 进行比较的神经解剖学
背景情况:
- 传统模型将上肢运动与皮质联系起来,并将平衡与大脑干联系起来.
- 动物研究表明,骨髓和脊髓对前肢控制有所贡献,但人类的相关性尚不清楚.
- 在手部运动中皮质,髓和脊柱电路之间的相互作用是不太了解的.
研究的目的:
- 为了研究调节前肢运动的皮质骨髓状网络在人类和小鼠.
- 阐明在手部运动过程中皮质,髓和脊柱运动区域之间的动态相互作用.
- 为了确定前肢运动控制的保存和特定物种的机制.
主要方法:
- 功能性磁共振成像 (fMRI) 研究在人类和小鼠执行前肢运动任务.
- 同时的脑脊磁fMRI绘制人类椎脊髓活动的地图.
- 在传感运动通路内分析皮质甲状腺合和功能连接.
主要成果:
- 识别了地形组织的皮质骨髓网络 (侧面面骨髓和尾骨髓),调节前肢运动.
- 观察到皮质骨结合的特定物种模式,与小鼠的运动皮层和人类更高阶的感觉运动区域有更强的联系.
- 揭示了人类C3-C4脊髓中独特的功能区域,腹部区域与髓和背部区域连接到下部段.
结论:
- 在哺乳动物中,一个保存的皮层骨髓网络是前肢运动控制的基础.
- 涉及视网脊髓和C3-C4自身脊髓系统的间接途径有助于精细的手部运动控制.
- 这些发现突出了物种间前肢运动控制中的皮层参与的保留机制和变异.
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