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固体瘤中最小残留疾病:临床应用和未来方向

Theresa Abdo¹, Ahmad Alhalabi¹, Sacha Yaghi²

¹Department of Hematology and Oncology Cleveland Clinic Florida, Maroone Cancer Center, Weston, Florida, USA.

|January 28, 2026

概括

使用循环瘤DNA (ctDNA) 检测最小残留疾病 (MRD) 显示出癌症监测和治疗决策的前景. 然而,在ctDNA测定标准化和成本方面的挑战阻碍了广泛的临床采用.

科学领域:

在瘤学瘤学.
分子诊断学分子诊断
生物标志物研究生物标志物研究

背景情况:

最小残留病 (MRD) 表示治疗后持续存在的癌细胞,不能通过标准方法检测到.
循环瘤DNA (ctDNA) 是敏感MRD检测的动态生物标志物,可实时监测和指导治疗决策.
基于ctDNA的MRD测定,瘤信息和瘤不可知,提供不同的灵敏度,特异性和临床可行性.

研究的目的:

审查基于ctDNA的MRD检测在固体瘤中的临床应用.
讨论阻碍ctDNAMRD在临床实践中的整合的局限性.
探索新兴技术和改善ctDNA MRD准确性和实用性的未来方向.

主要方法:

对各种恶性瘤中ctDNAMRD的最新临床试验和文献的审查.
对ctDNA MRD状态的预后和预测价值的分析.
评估挑战,包括瘤异质性,ctDNA分离变异性,试验标准化和成本效益.

主要成果:

治疗后的阳性ctDNAMRD状态与胃肠道,肺癌和乳腺癌的复发风险增加和生存率降低有关.
临床试验证明了ctDNA MRD.的预后和预测潜力.
将其纳入实践受限于技术和后勤方面的挑战.

结论:

ctDNA MRD是癌症管理的强大工具,提供实时洞察力和预后信息.
克服标准化,成本和试验解释方面的挑战对于更广泛的临床采用至关重要.
新兴技术和正在进行的试验有望提高ctDNA MRD的准确性并影响患者的治疗结果.

关键词:

癌症监测癌症监测癌症监测在循环中的瘤DNA.临床应用临床应用最少残留疾病的最小残留疾病.预后和预测性生物标志物.固体瘤是一种固体瘤.

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