在超重和肥胖的成年人中,脂肪组织衍生的小细胞外囊泡和血脑屏障功能
Shalini Mishra1, Yixin Su1, Sangeeta Singh1
1Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Experimental physiology
|January 28, 2026
概括
在肥胖中,脂肪组织 (sEVAT) 的小细胞外囊泡可能会损害血脑屏障 (BBB) 功能. 较高的sEVAT度与增加的脂肪度相关,可能导致超重和肥胖个体的BBB功能障碍.
科学领域:
- 神经科学是一个神经科学.
- 代谢综合征是代谢综合征的一种.
- 细胞生物学 细胞生物学
背景情况:
- 肥胖与大脑的变化有关,部分原因是脂肪组织与大脑之间的通信.
- 脂肪组织衍生的小细胞外囊泡 (sEVAT) 可以穿越血脑屏障 (BBB) 并影响大脑通路.
- sEVAT对肥胖患者的BBB完整性的影响以前没有研究过.
研究的目的:
- 在超重和肥胖的成年人中描述循环sEVAT.
- 为了在体外研究sEVAT对BBB透性的影响.
- 检查脂肪和体重减轻对sEVAT和BBB功能的影响.
主要方法:
- sEVAT从接受心脏康复 (CR) 或CR加减肥 (CR+WL) 的超重/肥胖成人血中分离出来.
- sEVAT以大小,度和蛋白质含量为特征.
- 使用体外BBB模型 (hCMEC/D3细胞) 来评估sEVAT对超内皮电阻 (TEER) 的影响.
主要成果:
- 与对照组相比,sEVAT治疗降低了BBB完整性,在72小时内显著降低了TEER的40%,与对照组相比.
- 在体重指数和体脂百分比较高的参与者中观察到较低的TEER.
- 在CR和CR+WL组之间没有发现TEER或sEVAT特征的显著差异,表明减肥干预没有改变这些结果.
结论:
- 在超重和肥胖的成年人中,血SEVAT度升高与脂肪增加有关.
- 这些sEVAT可能有助于减少BBB功能在肥胖的背景下.
- 需要进一步的研究来探索针对sEV的治疗策略,以减轻与肥胖有关的脑部变化.
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