供体通风持续时间较长与肺移植后的长期肺功能无关
Samuel Fioretti1, David Li1, Karina Kaur1
1Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Transplantation
|January 28, 2026
概括
肺移植前的长期供体通风 (DDV) 不会影响患者的肺功能结果. 然而,较长的DDV与捐赠肺中的阳性培养增加有关,这表明仔细选择捐赠者仍然至关重要.
科学领域:
- 胸部外科手术 胸部外科手术
- 移植医学 移植医学
- 肺部医学 肺部医学
背景情况:
- 长时间的机械通风会带来风险,例如呼吸机引起的肺损伤.
- 供体通风持续时间 (DDV) 对肺移植后肺功能的影响尚不清楚.
研究的目的:
- 为了研究双重肺移植后DDV和肺功能之间的关联.
- 评估二次结果,包括与DDV相关的移植功能障碍和死亡率.
主要方法:
- 分析了成年双重肺移植接受者 (2007-2020年) 的情况.
- 供体通风 (DDV) 的持续时间被评估为一个风险因素.
- 多变量回归分析了DDV和1年移植后FEV1% (1yFEV1%) 之间的关联.
主要成果:
- 较长的DDV没有与减少1yFEV1%或其他不良结果有关.
- 增加的DDV与对相关生物体的阳性供体支气管支气管洗培养相关 (每天OR 1.11).
结论:
- 在器官采购之前的DDV没有对1yFEV1%或次要结果产生负面影响.
- 可接受的供体肺与扩展通风可以安全考虑移植.
- 在捐赠者中,延长呼吸可能不会增加适合肺部呼吸器诱导的肺损伤的风险.
相关概念视频
Lung Capacity
56.3K
The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
56.3K
Pleura of the Lungs
7.1K
The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...
7.1K
Gross Anatomy of the Lungs
4.7K
The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...
4.7K
Mechanical Ventilation II: Invasive Ventilation
749
Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
749
Mechanical Ventilation III: Noninvasive Ventilation
587
Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation...
Noninvasive Positive-Pressure Ventilation...
587
Long-term Depression
33.3K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.3K


