在移动过程中对细胞类型特定的条状活动动态进行相辅相成的皮层和胸膜贡献.
Enida Gjoni1, Ram Dyuthi Sristi2, Haixin Liu1
1Department of Neurobiology, Center for Neural Circuits and Behavior, Department of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Science advances
|January 28, 2026
概括
大脑电路控制运动. 这项研究揭示了皮层和乳头输入如何在运动过程中驱动背侧条纹体 (DLS) 中的特定神经元类型,揭示了直接和间接通路中等状神经元 (dMSNs和iMSNs) 的不同作用.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 系统神经科学 系统神经科学
背景情况:
- 协调的运动行为依赖于在多个大脑区域的信息处理.
- 远程输入影响电机电路内的细胞类型特定活动的特定机制尚未完全理解.
- 背侧条纹体 (DLS),包括直接通路中状神经元 (dMSNs) 和间接通路中状神经元 (iMSNs),在运动控制中发挥着关键作用.
研究的目的:
- 调查皮层和胸膜输入如何调节熟练移动期间dMSNs和iMSNs的活动.
- 在MSN种群中识别功能上不同的子种群及其输入途径.
- 阐明皮质三角管和状三角管在传递运动相关信息中的作用.
主要方法:
- 单突触狂犬病追踪用于识别dMSN和iMSN的输入.
- 在小鼠进行熟练移动的体内电生理学记录.
- 循环神经网络 (RNN) 的分类和聚类分析,以确定神经元子群.
- 皮层或胸膜区域的不活化.
主要成果:
- 在dMSN,iMSN及其输入中观察到功能异质性,dMSN在运动开始/抵消时被激活,iMSN在执行时被激活.
- 皮质输入在开始/位期间优先活跃,而体输入在执行期间活跃.
- 在thalamic dMSN投射神经元和dMSN的一个子集中检测到运动阶段特定的节律活动.
- 皮层或丘脑的不活化导致MSN活动减少.
结论:
- 皮质前列腺和胸前列腺输入为DLS提供补充的运动信号.
- 这些信号通过共享和细胞类型特定的通路传递,影响dMSN和iMSN活动.
- 了解这些通路对于破译熟练运动控制的神经基础至关重要.
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