相关实验视频
Updated: Jan 30, 2026

16:49
Multifocal Electroretinograms
Published on: December 4, 2011
18.9K
在复发/耐药多发性骨髓瘤中,与elranatamab治疗相关的渐进性多焦点白细胞脑病变
Tansuhan Çetiner1, Merve Çağla Bilek1, Selin Arslan Kirezli1
1Department of Internal Medicine, Division of Hematology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
概括
针对BCMA的治疗方法Elranatamab可能与多发性骨髓瘤患者的渐进性多焦点白血脑病 (PML) 有关. 对于接受BCMA导向免疫疗法的患者来说,早期对JC病毒的监测至关重要.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 神经学 神经学
背景情况:
- 埃拉拉纳塔马布是一种针对BCMA和CD3的双特异性抗体,在复发性或耐火性多发性髓瘤 (RRMM) 中显示出有效性.
- 针对BCMA的双特异性抗体的安全性状况正在演变,进展性多焦点白血脑病 (PML) 以前没有系统地与elranatamab.描述.
研究的目的:
- 报告RRMM用elranatamab治疗的患者发生PML病例.
- 为了突出埃拉拉纳塔马布和JC病毒重新激活之间的潜在关联.
- 强调在接受BCMA向治疗的患者中对神经系统并发症的警的重要性.
主要方法:
- 一份病例报告显示,一名67岁的女性患者患有RRMM,接受了elranatamab治疗.
- 临床表现,神经成像 (MRI) 和脑脊液 (CSF) 聚合酶链反应 (PCR) 用于检测JC病毒.
- 停止使用埃拉拉纳塔马布,随后使用静脉注射免疫球蛋白,米尔塔扎平和尼沃卢马布进行治疗.
主要成果:
- 患者获得了对elranatamab的完全反应,但在七个循环后出现了神经症状 (肌痛,行走障碍).
- 大脑MRI揭示了多焦点白质病变,CSF PCR证实了JC病毒感染,诊断出PML.
- 尽管接受了治疗,但患者的神经状况恶化,需要重症监护.
结论:
- 埃拉拉纳塔马布治疗与导致PML的JC病毒重新激活之间存在可能的关联.
- 致病性可能涉及累积免疫抑制和埃拉拉纳他马布诱导的低麦球蛋白血症.
- 对于接受BCMA向免疫治疗的患者来说,对神经症状的警,早期的JC病毒检测和主动管理至关重要.
相关概念视频
Tumor Progression
7.4K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.4K
Gene Therapy
27.6K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.6K
Multiple Allele Traits
38.1K
The Concept of Multiple Allelism
38.1K
mTOR Signaling and Cancer Progression
4.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
4.8K
Group Therapy
429
Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
429
Multiple Regression
4.0K
Multiple regression assesses a linear relationship between one response or dependent variable and two or more independent variables. It has many practical applications.
Farmers can use multiple regression to determine the crop yield based on more than one factor, such as water availability, fertilizer, soil properties, etc. Here, the crop yield is the response or dependent variable as it depends on the other independent variables. The analysis requires the construction of a scatter plot...
Farmers can use multiple regression to determine the crop yield based on more than one factor, such as water availability, fertilizer, soil properties, etc. Here, the crop yield is the response or dependent variable as it depends on the other independent variables. The analysis requires the construction of a scatter plot...
4.0K

