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Updated: Jan 30, 2026

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造血干细胞移植后的怀孕:一项国际多中心研究
Nina Salooja1, Dirk-Jan Eikema2, David Michonneau3
1Centre for haematology, Hammersmith hospital, Imperial College, London, London, United Kingdom.
Blood advances
|January 28, 2026
概括
输血造血干细胞移植后的生育保护咨询至关重要. 这项研究发现怀孕的可能性因条件而异,降低强度条件 (RIC) 显示出更高的比率,辅助生殖技术 (ART) 发挥着重要作用.
科学领域:
- 血液学 血液学 血液学
- 生殖医学 生殖医学
- 在瘤学瘤学.
背景情况:
- 保持生育能力对于接受血造干细胞移植 (HSCT) 的生育年龄患者至关重要,这是由于治疗效应的消毒.
- 目前的移植前生育咨询缺乏全面的数据,影响了患者的准备.
- 怀孕后HSCT是罕见的,有限的数据阻碍了结果的解释.
研究的目的:
- 评估HSCT调节方案与随后的怀孕之间的关联.
- 调查辅助生殖技术 (ART) 对妊娠后HSCT的利用和影响.
- 为了描述接受HSCT的患者的怀孕结果.
主要方法:
- 一项多中心研究使用欧洲血液和骨髓移植学会 (EBMT) 注册数据在1995-2015年间移植的患者中确定了怀孕情况.
- 分析了54,323名HSCT患者,确定了621例怀孕和581例活产.
- 检查了调节方案,潜在疾病和ART在怀孕结果中的作用.
主要成果:
- 怀孕率因条件化方案而异,在减少强度条件化 (RIC) 后观察到的最高率.
- 33%的女性和56%的男性伴侣使用了ART;最高的使用是全身辐射 (TBI) 移植,最低的是RIC.
- 在女性中,怀孕与捐赠卵比与自身卵子,胚胎或组织更为常见.
结论:
- 降低强度调节 (RIC) 与血造干细胞移植后怀孕的可能性更高有关.
- 辅助生殖技术 (ART) 显著影响怀孕率和结果,可能会混自然生育保存的评估.
- 这些发现为改善HSCT患者的移植前生育保护咨询和服务提供了关键数据.
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